1. Chronic Obstructive Pulmonary Disease Is Not Associated with KRAS Mutations in Non-Small Cell Lung Cancer
- Author
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Arja ter Elst, Harry J.M. Groen, Wim Timens, Maarten van den Berge, Gerald S. M. A. Kerner, Ali Saber, T. Jeroen N. Hiltermann, Ed Schuuring, Anke van den Berg, Anthonie J. van der Wekken, Groningen Research Institute for Asthma and COPD (GRIAC), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Targeted Gynaecologic Oncology (TARGON), Stem Cell Aging Leukemia and Lymphoma (SALL), Translational Immunology Groningen (TRIGR), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)
- Subjects
Male ,0301 basic medicine ,Oncology ,Lung Neoplasms ,Pulmonology ,Vital Capacity ,Gene mutation ,SUSCEPTIBILITY ,medicine.disease_cause ,Lung and Intrathoracic Tumors ,Pulmonary function testing ,Pulmonary Disease, Chronic Obstructive ,Habits ,0302 clinical medicine ,Carcinoma, Non-Small-Cell Lung ,Forced Expiratory Volume ,Adenocarcinomas ,Medicine and Health Sciences ,Smoking Habits ,COPD ,Multidisciplinary ,Smoking ,Middle Aged ,ErbB Receptors ,KRAS Mutation Analysis ,030220 oncology & carcinogenesis ,Medicine ,Female ,KRAS ,Anatomy ,GENE-MUTATIONS ,Research Article ,EXPRESSION ,medicine.medical_specialty ,Histology ,SEX-DIFFERENCES ,Science ,Chronic Obstructive Pulmonary Disease ,EGFR ,Carcinomas ,Proto-Oncogene Proteins p21(ras) ,03 medical and health sciences ,FEV1/FVC ratio ,Sex Factors ,Diagnostic Medicine ,Internal medicine ,Genetics ,medicine ,Adenocarcinoma of the lung ,Humans ,Genetic Predisposition to Disease ,Lung cancer ,neoplasms ,Aged ,Behavior ,business.industry ,Cancers and Neoplasms ,Biology and Life Sciences ,ADENOCARCINOMA ,medicine.disease ,Non-Small Cell Lung Cancer ,respiratory tract diseases ,030104 developmental biology ,CIGARETTE-SMOKE ,Mutation ,RISK-FACTORS ,business ,GROWTH-FACTOR RECEPTOR - Abstract
Mutations in epithelial growth factor receptor (EGFR), as well as in the EGFR downstream target KRAS are frequently observed in non-small cell lung cancer (NSCLC). Chronic obstructive pulmonary disease (COPD), an independent risk factor for developing NSCLC, is associated with an increased activation of EGFR. In this study we determined presence of EGFR and KRAS hotspot mutations in 325 consecutive NSCLC patients subjected to EGFR and KRAS mutation analysis in the diagnostic setting and for whom the pulmonary function has been determined at time of NSCLC diagnosis. Information about age at diagnosis, sex, smoking status, forced vital capacity (FVC) and forced expiratory volume in 1 sec (FEV1) was collected. Chronic obstructive pulmonary disease(COPD) was defined according to 2013 GOLD criteria. Chi-Square, student t-test and multivariate logistic regression were used to analyze the data. A total of 325 NSCLC patients were included, 193 with COPD and 132 without COPD. COPD was not associated with presence of KRAS hotspot mutations, while EGFR mutations were significantly higher in non-COPD NSCLC patients. Both female gender (HR 2.61; 95% CI: 1.56-4.39; pT and G>C transversions were significantly more frequent in females (86.2%) than in males (61.5%) (p = 0.008). The exon 19del mutation was more frequent in non-smokers (90%) compared to current or past smokers (36.8%). In conclusion, KRAS mutations are more common in females and smokers, but are not associated with COPD-status in NSCLC patients. EGFR mutations are more common in non-smoking NSCLC patients.
- Published
- 2016