1. Diagnostic Accuracy of Gd-EOB-DTPA for Detection Hepatocellular Carcinoma (HCC): A Comparative Study with Dynamic Contrast Enhanced Magnetic Resonance Imaging (MRI) and Dynamic Contrast Enhanced Computed Tomography (CT)
- Author
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Marta Puglia, Massimo Imbriaco, Simone Maurea, Michele Klain, Serena De Luca, Mario Fusari, P.P. Mainenti, Raffaele Liuzzi, Milena Coppola, Imbriaco, Massimo, DE LUCA, Serena, Coppola, M, Fusari, Mario, Klain, Michele, Puglia, M. A, Mainenti, PIER PAOLO, Liuzzi, Raffaele, and Maurea, Simone
- Subjects
medicine.medical_specialty ,Tomography Scanners, X-Ray Computed ,Contrast Media ,Gd-EOB-DTPA ,Diagnostic accuracy ,contrast media ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,tomography scanners ,0302 clinical medicine ,medicine ,magnetic resonance imaging ,x-ray computed ,liver neoplasms ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Liver Neoplasms ,Area under the curve ,Magnetic resonance imaging ,Dynamic Contrast Enhanced Computed Tomography ,medicine.disease ,Magnetic Resonance Imaging ,3. Good health ,Liver Neoplasm ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Original Article ,Radiology ,business ,Nuclear medicine ,Preclinical imaging - Abstract
BACKGROUND: To compare the diagnostic accuracy of hepato-biliary (HB) phase with gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) with dynamic contrast-enhanced MR imaging (DCEMRI) and contrast-enhanced CT (DCECT) for hepatocellular carcinoma (HCC) detection. MATERIAL AND METHODS: 73 patients underwent DCECT and Gd-EOB-DTPA-3T-MR. Lesions were classified using a five-point confidence scale. Reference standard was a combination of pathological evidence and tumor growth at follow-up CT/MR at 12 months. Receiver Operating Characteristic (ROC) curves were obtained. RESULTS: A total of 125 lesions were confirmed in 73 patients. As many as 74 were HCCs and 51 were benign. Area under the curve (AUC) was 0.984 for DCEMRI+HB phase vs. 0.934 for DCEMRI (p20 mm (n.40), AUC was 0.984 for DCEMRI+HB phase, 0.999 for DCEMRI, and 0.913 for DCECT, (p=n.s.). For lesions 20 mm and patients with Child-Pugh class B or C.
- Published
- 2017
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