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A scientific field experiment was conducted during 2017, 2018 and 2019 in kharif season at R.A.R.S, Nandyal, Acharya N.G. Ranga Agricultural University to study Efficacy of Neem coated urea through nitrogen use efficiency methods in Bt cotton. The experiment consisting of seven nitrogen use efficiency treatments with combination of three nitrogen doses viz: No nitrogen, 75% recommended dose of nitrogen, 100% recommended dose of nitrogen, 2 methods of nitrogen application viz: band application and split application and 4 stages of nitrogen top dressing viz: basal, squaring, flowering and boll development stages along with foliar application of 1% urea at squaring, flowering, boll development stage with RBD design and replicated thrice. The results indicated that pooled seed cotton yield (2813 kg/ha), nutrient uptake and cotton economics were higher with spot application 75% recommended dose of nitrogen with 4 split doses of nitrogen along with foliar application of 1% urea at squaring, flowering and boll developmental stage and was on par with spot application of 75% recommended dose of nitrogen with 4 split doses of nitrogen, foliar application of 1% urea at squaring, flowering and boll developmental stage along with incorporation of fodder cowpea before flowering (2681 kg/ ha). Lower seed cotton yield (1637 kg/ ha) was recorded with no nitrogen treatment.