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2. Trimester specific reference ranges for serum TSH and Free T4 among United Arab Emirates pregnant women

Author

Aly Bernard Khalil, Bashir Taha Salih, Onismos Chinengo, Ma Remy D. Bardies, Andrew Turner, and Laila O. Abdel Wareth

Subjects
Medicine (General), R5-920, Chemistry, QD1-999
Abstract

Background: The American Thyroid Association (ATA) recommended the establishment of population specific reference ranges for thyroid hormones during pregnancy. Initial studies conducted in the United Arab Emirates (UAE) in 2003 and 2004 on pregnant women published a considerably higher upper limit for thyroid stimulating hormone (TSH) than that proposed by ATA. The UAE was classified as a country with mild iodine deficiency at the time of this initial study. After the implementation of aggressive strategies to address iodine deficiency over the last decade, the UAE was recently declared as iodine sufficient. The current study re-evaluates the reference intervals for thyroid hormones for pregnant women in the UAE after the declaration of iodine sufficiency status. Methods: TSH and free thyroxin (FT4) from 414 UAE national pregnant females were analyzed to determine trimester specific reference ranges. Results: The upper limits of the TSH reference ranges were found to be significantly lower than previously reported, but still higher than those recommended by ATA in 2011.FT4 reference ranges were found to be slightly lower than previously reported. Conclusion: TSH trimester specific reference ranges in UAE national pregnant women are higher than those recommended by ATA in 2011 but in keeping with the latest guidelines published in 2017. This should be considered while interpreting thyroid function tests in this population. Further studies including urinary iodine measurement, body mass index and larger numbers per partition in this population are recommended. Keywords: Reference intervals, Gestation, Thyroid stimulating hormone, Pregnancy, Free thyroxin

Published
2018
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3. Trimester specific reference ranges for serum TSH and Free T4 among United Arab Emirates pregnant women

Author

Bashir Taha Salih, Andrew Turner, Laila Abdel Wareth, Ma Remy D. Bardies, Onismos Chinengo, and Aly B Khalil

Subjects
endocrine system, medicine.medical_specialty, Clinical Biochemistry, Population, 030209 endocrinology & metabolism, Thyroid function tests, Article, lcsh:Chemistry, 03 medical and health sciences, 0302 clinical medicine, Thyroid-stimulating hormone, Pregnancy, Thyroid stimulating hormone, Medicine, education, lcsh:R5-920, education.field_of_study, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Obstetrics, Thyroid, Reference intervals, medicine.disease, Iodine deficiency, medicine.anatomical_structure, Free thyroxin, lcsh:QD1-999, 030220 oncology & carcinogenesis, Gestation, lcsh:Medicine (General), business, Body mass index
Abstract

Background: The American Thyroid Association (ATA) recommended the establishment of population specific reference ranges for thyroid hormones during pregnancy. Initial studies conducted in the United Arab Emirates (UAE) in 2003 and 2004 on pregnant women published a considerably higher upper limit for thyroid stimulating hormone (TSH) than that proposed by ATA. The UAE was classified as a country with mild iodine deficiency at the time of this initial study. After the implementation of aggressive strategies to address iodine deficiency over the last decade, the UAE was recently declared as iodine sufficient. The current study re-evaluates the reference intervals for thyroid hormones for pregnant women in the UAE after the declaration of iodine sufficiency status. Methods: TSH and free thyroxin (FT4) from 414 UAE national pregnant females were analyzed to determine trimester specific reference ranges. Results: The upper limits of the TSH reference ranges were found to be significantly lower than previously reported, but still higher than those recommended by ATA in 2011.FT4 reference ranges were found to be slightly lower than previously reported. Conclusion: TSH trimester specific reference ranges in UAE national pregnant women are higher than those recommended by ATA in 2011 but in keeping with the latest guidelines published in 2017. This should be considered while interpreting thyroid function tests in this population. Further studies including urinary iodine measurement, body mass index and larger numbers per partition in this population are recommended. Keywords: Reference intervals, Gestation, Thyroid stimulating hormone, Pregnancy, Free thyroxin

Published
2018

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