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Social jetlag is a discordance between the social and biological rhythm and is associated with higher HbA1c, higher BMI, and higher odds of obesity. The pathways that could explain these associations are still debated. This study aims to assess the mediating role of several lifestyle factors in the cross-sectional association between social jetlag and BMI. We used cross-sectional data from 1784 adults from urban areas in the Netherlands, collected in 2019. Social jetlag (difference in midpoint of sleep between week and weekend nights) was categorized as low(<1 h), moderate(1−2 h), and high(>2 h). BMI(kg/m2) was calculated from self-reported height and weight. The association between social jetlag and BMI was assessed using linear regression, adjusted for sex, age, education, and sleep duration and stratified for the effect modifier stress (high vs. low). Mediation analysis was performed for self-reported smoking, physical activity, alcohol consumption, and adherence to a healthy diet. High social jetlag was associated with higher BMI (0.69 kg/m2,95%CI 0.05;1.33). This association was stronger in people with high stress (0.93 kg/m2,95%CI 0.09;1.76). Social jetlag was also associated with higher odds of smoking, lower physical activity, higher alcohol consumption, and lower healthy diet adherence. In people with high stress, these factors mediated 10–15% of the association between social jetlag and BMI. Social jetlag is associated with higher BMI and this association is stronger in people with high stress. In people with high stress, healthy diet adherence mediated 12% of this association. Other pathways involved in this association should be further investigated. • Social jetlag is associated with higher BMI in adults. • Social jetlag is associated with several unhealthy lifestyle factors. • Diet significantly mediates 12% of the association between social jetlag and BMI. • Other pathways involved in this association should be further investigated. [ABSTRACT FROM AUTHOR]

Background. From a preventive point of view, it is especially important to investigate the life style risk factors connected to cardiovascular disease (CVD) biological risk factors clustering. The purposes of this study were (I) to determine in pediatric population the coexistence of biological cardiovascular disease risk factors (high blood pressure (HBP), percentage of high fat mass (%HFM), and high total cholesterol (HTC)) and (II) to study the relationship between low physical activity, a lifestyle risk factor, with those biological risk factors.Methods. This study comprised 1461 children (699 males and 762 females) aged between 8 and 15 years old. The following measurements were carried out: blood pressure, percentage of fat mass, total cholesterol (TC), and physical activity. The quartiles, adjusted for age and gender, were the criterion used to classify the subjects at risk. Odds ratios and confidence intervals at 95% were used to study HBP, HTC, and %HFM clustering in both genders. Multinomial logistic regression was used to investigate the relationship between clustering and physical activity index (PAI).Results. The findings of this study indicated that there is clustering for the biological risk factors, specially between HBP and %HFM for females. It can be observed that about half of the subjects had at least one biological risk factor.Conclusions. The results of the present study suggest that children and adolescents with higher PAI have a lower number of biological risk factors for CVD. [Copyright &y& Elsevier]