1. Evaluating FINDRISC as a screening tool for type 2 diabetes among overweight adults in the PREVIEW:NZ cohort
- Author
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Yannan Jiang, Hannah Chisholm, Marta P. Silvestre, Wonjoo Lee, Sally D. Poppitt, and Katya Volkova
- Subjects
Adult ,Blood Glucose ,Male ,medicine.medical_specialty ,Diabetes risk ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,Population ,030209 endocrinology & metabolism ,Type 2 diabetes ,Overweight ,Impaired glucose tolerance ,Prediabetic State ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Surveys and Questionnaires ,Internal Medicine ,medicine ,Humans ,Mass Screening ,030212 general & internal medicine ,Prediabetes ,education ,education.field_of_study ,Nutrition and Dietetics ,business.industry ,Incidence ,nutritional and metabolic diseases ,Reproducibility of Results ,Glucose Tolerance Test ,Middle Aged ,Impaired fasting glucose ,medicine.disease ,Diabetes Mellitus, Type 2 ,ROC Curve ,Area Under Curve ,Cohort ,Physical therapy ,Female ,medicine.symptom ,Family Practice ,business ,Risk Reduction Behavior ,Biomarkers ,New Zealand - Abstract
Aims This study aimed to evaluate the efficacy of a high (≥12) Finnish diabetes risk (FINDRISC) score in identifying undiagnosed prediabetes and type 2 diabetes (T2D) in an New Zealand population of overweight and obese individuals, across a variety of ethnic groups. Methods We estimated the efficacy of elevated FINDRISC scores in predicting prediabetes and T2D in 424 overweight adults with no prior diagnosis recruited for the PREVention of diabetes through lifestyle Interventions in Europe and Worldwide (PREVIEW) study. All participants who completed the FINDRISC questionnaire during a pre-screening phase with a score of ≥12 were then screened using a 2 h oral glucose tolerance test (2h-OGTT) to identify undiagnosed dysglycaemia. Results Of the 424 participants, 65% (n = 280) were pre-diabetic and 7% (n = 32) had undiagnosed T2D. A higher FINDRISC score was significantly associated with prediabetes and T2D (P = 0.02). There was a significant association between ethnicity and glycaemic status (normal vs prediabetes/T2D, P = 0.02). Increasing the FINDRISC cut-off to ≥15 resulted in a non-significant increase in the proportion of participants correctly classified with dysglycaemia. ROC-AUC = 0.6 with sensitivity = 0.6026 (95% CI: 0.5459–0.6573) and specificity = 0.5536 (95% CI: 0.4567–0.6476). Isolated impaired fasting glucose (IFG) was more efficient in predicting dysglycaemia than isolated impaired glucose tolerance (IGT). Conclusions The FINDRISC questionnaire is a useful and efficacious screening tool to identify unknown prediabetes and T2D in overweight New Zealanders, particularly in Maori individuals.
- Published
- 2017