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This paper discusses the concepts involved in national-regional innovation systems (N-R_I_S) in light of the emergence of knowledge capitalism as a new phase of development, and the neoliberal appropriation of these concepts, pursuant to neoliberalism's position as the predominant development path in this new phase. Against that backdrop, this study looks at the experience of Jalisco, Mexico, the only state that has conceived of and put into practice a development strategy centered on an N-R_I_S and anchored in the electronics-computing and telecommunications sectors, on the neoliberal path the country is following. This study concludes that despite progress made, the fact that public-private partnerships are the main way this strategy operates has prevented the state from gaining a strategic position in the region from the standpoint of developing knowledge capitalism in Mexico and the breach of a "glocalizing" spatiality. [ABSTRACT FROM AUTHOR]