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Your search keyword '"P. V. Kurman"' showing total 2 results
Start Over Author "P. V. Kurman" Journal proceedings of the national academy of sciences of belarus, chemical series
2 results on '"P. V. Kurman"'

1. Synthesis of leucine-based cyclic dipeptides

Author

P. V. Kurman, V. A. Haidukevich, V. A. Knizhnikov, and L. A. Popova

Subjects
Inorganic Chemistry, Chemistry (miscellaneous), Chemistry, Stereochemistry, Organic Chemistry, Peptide bond, Leucine, Analytical Chemistry
Abstract

3-benzyl-6-isobutylpiperazin-2,5-dione [cyclo(leucylphenylalanyl)], 3-isobutylpiperazin-2,5-dione [cyclo(-leucylglycyl)] and 3-(sec-butyl-)-6-isobutyl-piperazine-2,5-dione [cyclo(leucylisoleucine)] have been obtained by cyclization of methyl esters of tert-butyloxycarbonyl derivatives of dipeptides, for the synthesis of which both carbodiimide-promoted peptide bond formation and the mixed anhydride method were used.

Published
2020

2. Synthesis of acylic derivatives of prolylleucylglycinamide

Author

Vladimir I. Potkin, P. V. Kurman, Z. I. Kuvaeva, V. A. Knizhnikov, V. A. Haidukevich, Sergey K. Petkevich, and E. G. Karankevich

Subjects
chemistry.chemical_classification, Base (chemistry), Formic acid, Organic Chemistry, Ethyl ester, Analytical Chemistry, Inorganic Chemistry, chemistry.chemical_compound, Ammonia, Glycine amide, chemistry, Chemistry (miscellaneous), Organic chemistry, Hydrogen chloride
Abstract

Tert-butyloxycarbonylprolylleucylglycinamide is obtained both by the interaction of tert-butyloxycarbonylprol ylleucylglycine ethyl ester with a methanolic ammonia solution and by the reaction of glycine amide with a mixed anhydride which was synthesized from tert-butyloxycarbonylprolylleucine and isobutylchloroformate. The removal of the tert-butyloxycarbonyl group by the action of formic acid or a dioxane solution of hydrogen chloride and treatment of the resulting salts with the corresponding base yielded a prolylleucylglycinamide, by the interaction of which with acetic, benzoic or 5-phenylisoxazole-3-carboxylic acids chlorides acyl derivatives of prolylleucylglycinamide are obtained.

Published
2019

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