Search

Your search keyword '"Gross, S.S."' showing total 1 results
Start Over Author "Gross, S.S." Journal proceedings of the national academy of sciences of the united states
1 results on '"Gross, S.S."'

1. Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms

Author

Brandi, M.L., Hukkanen, M., Umeda, T., Moradi-Bidhendi, N., Bianchi, S., Gross, S.S., Polak, J.M., and MacIntyre, I.

Subjects
Bones -- Growth, Nitric oxide -- Physiological aspects, Immunocytochemistry -- Analysis, Science and technology
Abstract

Immunocytochemistry and Northern blotting during bidirectional regulation of osteoclasts function by nitric oxide, shows the presence of the constitutive calcium-sensitive nitric oxide synthase (cNOS) isoform in normal rat osteoclasts, and in human preosteoclast cell line. The presence of inducible (I) NOS isoform was also demonstrated. A basal level of transcript was observed in human preosteoclast line. Osteoclasts function may require continuous increases in NO production by cNOS against a basal inhibitory background activity of the iNOS isoform.

Published
1995

Catalog

Books, media, physical & digital resources
See catalog results