1. Tas2R activation relaxes airway smooth muscle by release of Gα
- Author
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Yu-Wei, Zhou, Jie, Sun, Ye, Wang, Cai-Ping, Chen, Tao, Tao, Ming, Ma, Xin, Chen, Xue-Na, Zhang, Li-Yuan, Yang, Zhong-Liang, Zhang, Ye-Qiong, Li, Zhi-Hui, Jiang, Tian-Tian, Qiu, Han, Wang, Yang, Pan, Jian, Zhang, Hua-Qun, Chen, Pei, Wang, and Min-Sheng, Zhu
- Subjects
Transcriptional Activation ,Pulmonary Disease, Chronic Obstructive ,Myocytes, Smooth Muscle ,Animals ,Calcium ,Muscle, Smooth ,Asthma ,Bronchodilator Agents ,Rats ,Receptors, G-Protein-Coupled ,Signal Transduction - Abstract
Both chronic obstructive pulmonary disease (COPD) and asthma are severe respiratory diseases. Bitter receptor-mediated bronchodilation is a potential therapy for asthma, but the mechanism underlying the agonistic relaxation of airway smooth muscle (ASM) is not well defined. By exploring the ASM relaxation mechanism of bitter substances, we observed that pretreatment with the bitter substances nearly abolished the methacholine (MCh)-induced increase in the ASM cell (ASMC) calcium concentration, thereby suppressing the calcium-induced contraction release. The ASM relaxation was significantly inhibited by simultaneous deletion of three Gα
- Published
- 2022