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Your search keyword '"Heinemann, Stephen F."' showing total 25 results
Start Over Author "Heinemann, Stephen F." Journal proceedings of the national academy of sciences of the united states of america
25 results on '"Heinemann, Stephen F."'

1. Astrocytes contribute to gamma oscillations and recognition memory

Author

Lee, Hosuk Sean, Ghetti, Andrea, Pinto-Duarte, António, Wang, Xin, Dziewczapolski, Gustavo, Galimi, Francesco, Huitron-Resendiz, Salvador, Piña-Crespo, Juan C, Roberts, Amanda J, Verma, Inder M, Sejnowski, Terrence J, and Heinemann, Stephen F

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Medical Physiology, Neurosciences, Psychology, Mental Health, Behavioral and Social Science, Brain Disorders, Basic Behavioral and Social Science, Aetiology, 2.1 Biological and endogenous factors, Underpinning research, 1.1 Normal biological development and functioning, Mental health, Neurological, Animals, Astrocytes, Brain Waves, Calcium Signaling, Carbachol, Electroencephalography, Gene Expression, Glutamic Acid, Hippocampus, Metalloendopeptidases, Mice, Mice, Inbred C57BL, Mice, Transgenic, Models, Neurological, Nerve Net, Recognition, Psychology, Recombinant Proteins, Synaptic Transmission, Tetanus Toxin, Tissue Culture Techniques, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, glia, electroencephalogram, network oscillation, gliotransmitter, glial fibrillary acidic protein
Abstract

Glial cells are an integral part of functional communication in the brain. Here we show that astrocytes contribute to the fast dynamics of neural circuits that underlie normal cognitive behaviors. In particular, we found that the selective expression of tetanus neurotoxin (TeNT) in astrocytes significantly reduced the duration of carbachol-induced gamma oscillations in hippocampal slices. These data prompted us to develop a novel transgenic mouse model, specifically with inducible tetanus toxin expression in astrocytes. In this in vivo model, we found evidence of a marked decrease in electroencephalographic (EEG) power in the gamma frequency range in awake-behaving mice, whereas neuronal synaptic activity remained intact. The reduction in cortical gamma oscillations was accompanied by impaired behavioral performance in the novel object recognition test, whereas other forms of memory, including working memory and fear conditioning, remained unchanged. These results support a key role for gamma oscillations in recognition memory. Both EEG alterations and behavioral deficits in novel object recognition were reversed by suppression of tetanus toxin expression. These data reveal an unexpected role for astrocytes as essential contributors to information processing and cognitive behavior.

Published
2014

5. Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures

Author

Kerjan, Géraldine, Koizumi, Hiroyuki, Han, Edward B, Dubé, Celine M, Djakovic, Stevan N, Patrick, Gentry N, Baram, Tallie Z, Heinemann, Stephen F, and Gleeson, Joseph G

Subjects
Epilepsy, Brain Disorders, Neurosciences, Neurodegenerative, 2.1 Biological and endogenous factors, Aetiology, Neurological, Animals, Cell Differentiation, Cell Polarity, Dendrites, Doublecortin Domain Proteins, Doublecortin Protein, Hippocampus, Interneurons, Mice, Mice, Knockout, Microtubule-Associated Proteins, Neurons, Neuropeptides, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins c-fos, Pyramidal Cells, Seizures, Somatostatin, Survival Analysis, Synapses, Weaning, gamma-Aminobutyric Acid, epilepsy, receptive field, pyramidal neuron, dendrites, delamination
Abstract

Mutations in doublecortin (DCX) are associated with intractable epilepsy in humans, due to a severe disorganization of the neocortex and hippocampus known as classical lissencephaly. However, the basis of the epilepsy in lissencephaly remains unclear. To address potential functional redundancy with murin Dcx, we targeted one of the closest homologues, doublecortin-like kinase 2 (Dclk2). Here, we report that Dcx; Dclk2-null mice display frequent spontaneous seizures that originate in the hippocampus, with most animals dying in the first few months of life. Elevated hippocampal expression of c-fos and loss of somatostatin-positive interneurons were identified, both known to correlate with epilepsy. Dcx and Dclk2 are coexpressed in developing hippocampus, and, in their absence, there is dosage-dependent disrupted hippocampal lamination associated with a cell-autonomous simplification of pyramidal dendritic arborizations leading to reduced inhibitory synaptic tone. These data suggest that hippocampal dysmaturation and insufficient receptive field for inhibitory input may underlie the epilepsy in lissencephaly, and suggest potential therapeutic strategies for controlling epilepsy in these patients.

Published
2009

10. Workshop on Schizophrenia

Author

Barondes, Samuel H., Alberts, Bruce M., Andreasen, Nancy C., Bargmann, Cornelia, Benes, Francine, Goldman-Rakic, Patricia, Gottesman, Irving, Heinemann, Stephen F., Jones, Edward G., Kirschner, Marc, Lewis, David, Raff, Martin, Roses, Allen, Rubenstein, John, Snyder, Solomon, Watson, Stanley J., Weinberger, Daniel R., and Yolken, Robert H.

Published
1997

11. Correction for Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

Author

Talantova, Maria, Sanz-Blasco, Sara, Zhang, Xiaofei, Xia, Peng, Akhtar, Mohd Waseem, Okamoto, Shu-ichi, Dziewczapolski, Gustavo, Nakamura, Tomohiro, Cao, Gang, Pratt, Alexander E., Kang, Yeon-Joo, Tu, Shichun, Molokanova, Elena, McKercher, Scott R., Hires, Samuel Andrew, Sason, Hagit, Stouffer, David G., Buczynski, Matthew W., Solomon, James P., Michael, Sarah, Powers, Evan T., Kelly, Jeffery W., Roberts, Amanda, Tong, Gary, Fang-Newmeyer, Traci, Parker, James, Holland, Emily A., Zhang, Dongxian, Nakanishi, Nobuki, Chen, H.-S. Vincent, Wolosker, Herman, Wang, Yuqiang, Parsons, Loren H., Ambasudhan, Rajesh, Masliah, Eliezer, Heinemann, Stephen F., Piña-Crespo, Juan C., and Lipton, Stuart A.

Published
2013

12. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

Author

Talantova, Maria, Sanz-Blasco, Sara, Zhang, Xiaofei, Xia, Peng, Akhtar, Mohd Waseem, Okamoto, Shu-ichi, Dziewczapolski, Gustavo, Nakamura, Tomohiro, Cao, Gang, Pratt, Alexander E., Kang, Yeon-Joo, Tu, Shichun, Molokanova, Elena, McKercher, Scott R., Hires, Samuel Andrew, Sason, Hagit, Stouffer, David G., Buczynski, Matthew W., Solomon, James P., Michael, Sarah, Powers, Evan T., Kelly, Jeffery W., Roberts, Amanda, Tong, Gary, Fang-Newmeyer, Traci, Parker, James, Holland, Emily A., Zhang, Dongxian, Nakanishi, Nobuki, Chen, H.-S. Vincent, Wolosker, Herman, Wang, Yuqiang, Parsons, Loren H., Ambasudhan, Rajesh, Masliah, Eliezer, Heinemann, Stephen F., Piña-Crespo, Juan C., and Lipton, Stuart A.

Published
2013

25. Alpha10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and...

Author

Elgoyhen, A. Belen, Vetter, Douglas E., Katz, Eleonora, Rothlin, Carla V., Heinemann, Stephen F., and Boulter, Jim

Subjects
NICOTINIC receptors, ACETYLCHOLINE
Abstract

Reports on the cloning and characterization of rat alpha10, a member of the nicotinic acetylcholine receptor (nAChR) subunit gene family. Pharmacological profiles of homomeric alpha 9; Role of alpha10 in nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechasensory hair cells.

Published
2001
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