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Your search keyword '"Kopp, Jeffrey B."' showing total 7 results
Start Over Author "Kopp, Jeffrey B." Journal proceedings of the national academy of sciences of the united states of america
7 results on '"Kopp, Jeffrey B."'

7. Podocytes use FcRn to clear lgG from the glomerular basement membrane.

Author

Akilesh, Shreeram, Huber, Tobias B., Hui Wu, Wang, Gary, Hartleben, Björn, Kopp, Jeffrey B., Miner, Jeffrey H., Roopenian, Deny C., Unanue, Emil R., and Shaw, Andrey S.

Subjects
GLOMERULAR filtration rate, KIDNEY function tests, KIDNEY glomerulus, BIOLOGICAL membranes, URINARY organs, PLASMA cells
Abstract

The glomerular filtration barrier prevents large serum proteins from being lost into the urine. It is not known, however, why the filter does not routinely dog with large proteins that enter the glomerular basement membrane (GBM). Here, we provide evidence that an active transport mechanism exists to remove immunoglobulins that accumulate at the filtration barrier. We found that FcRn, an lgG and albumin transport receptor, is expressed in podocytes and functions to internalize lgG from the GBM. Mice lacking FcRn accumulated lgG in the GBM as they aged, and tracer studies showed delayed clearance of lgG from the kidneys of FcRn-deficient mice. Supporting a role for this pathway in disease, saturating the clearance mechanism potentiated the pathogenicity of nephrotoxic sera. These studies support the idea that podocytes play an active role in removing proteins from the GBM and suggest that genetic or acquired impairment of the clearance machinery is likely to be a common mechanism promoting glomerular diseases. [ABSTRACT FROM AUTHOR]

Published
2008
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