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Your search keyword '"Nagao, Soichi"' showing total 8 results
Start Over Author "Nagao, Soichi" Journal proceedings of the national academy of sciences of the united states of america
8 results on '"Nagao, Soichi"'

7. Dual Involvement of G-substrate in Motor Learning Revealed by Gene Deletion

Author

Endo, Shogo, Shutoh, Fumihiro, Le Dinh, Tung, Okamoto, Takehito, Ikeda, Toshio, Suzuki, Michiyuki, Kawahara, Shigenori, Yanagihara, Dai, Sato, Yamato, Yamada, Kazuyuki, Sakamoto, Toshiro, Kirino, Yutaka, Hartell, Nicholas A., Yamaguchi, Kazuhiko, Itohara, Shigeyoshi, Nairn, Angus C., Greengard, Paul, Nagao, Soichi, and Ito, Masao

Published
2009
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8. Lipid signaling in cytosolic phospholipase A2α– cyclooxygenase-2 cascade mediates cerebellar long- term depression and motor learning.

Author

Le, Tung Dinh, Shirai, Yoshinori, Okamoto, Takehito, Tatsukawa, Tetsuya, Nagao, Soichi, Shimizu, Takao, and Ito, Masao

Subjects
PHOSPHOLIPASES, CYCLOOXYGENASE 2, MENTAL depression, MOTOR learning, NEUROPLASTICITY, PURKINJE cells, ARACHIDONIC acid, PROSTAGLANDINS
Abstract

In this study, we show the crucial roles of lipid signaling in longterm depression (LTD), that is, synaptic plasticity prevailing in cerebellar Purkinje cells. In mouse brain slices,, we found that cPLA2a knockout blocked LTD induction, which was rescued by replenishing arachidonic acid (AA) or prostaglandin (PG) D2 or E2. Moreover, cyclooxygenase (COX)-2 inhibitors block LTD, which is rescued by supplementing PGD2/E2. The blockade or rescue occurs when these reagents are applied within a time window of 5-15 mm following the onset of LTD-inducing stimulation. Furthermore, PGD2/E2 facilitates the chemical induction of LTD by a PKC activator but is unable to rescue the LTD blocked by a PKC inhibitor. We conclude that PGD2/E2 mediates LTD jointly with PKC, and suggest possible pathways for their interaction. Finally, we demonstrate in awake mice that cPLA2α deficiency or COX-2 inhibition attenuates short-term adaptation of optokinetic eye movements, supporting the view that LTD underlies motor learning. [ABSTRACT FROM AUTHOR]

Published
2010
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