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Your search keyword '"Peterson, Scott N."' showing total 5 results
Start Over Author "Peterson, Scott N." Journal proceedings of the national academy of sciences of the united states of america
5 results on '"Peterson, Scott N."'

1. Identification of Anthrax Toxin Genes in a Bacillus cereus Associated with an Illness Resembling Inhalation Anthrax

Author

Hoffmaster, Alex R., Ravel, Jacques, Rasko, David A., Chapman, Gail D., Chute, Michael D., Marston, Chung K., De, Barun K., Sacchi, Claudio T., Fitzgerald, Collette, Mayer, Leonard W., Priest, Fergus G., Barker, Margaret, Jiang, Lingxia, Cer, Regina Z., Rilstone, Jennifer, Peterson, Scott N., Weyant, Robbin S., Galloway, Darrell R., Read, Timothy D., Popovic, Tanja, Fraser, Claire M., and Robbins, John B.

Published
2004

2. Microbiota organization is a distinct feature of proximal colorectal cancers

Author

Dejea, Christine M., Wick, Elizabeth C., Hechenbleikner, Elizabeth M., White, James R., Welch, Jessica L. Mark, Rossetti, Blair J., Peterson, Scott N., Snesrud, Erik C., Borisy, Gary G., Lazarev, Mark, Stein, Ellen, Vadivelu, Jamuna, Roslani, April C., Malik, Ausuma A., Wanyiri, Jane W., Goh, Khean L., Thevambiga, Iyadorai, Fu, Kai, Wan, Fengyi, Llosa, Nicolas, Housseau, Franck, Romans, Katharine, Wu, XinQun, McAllister, Florencia M., Wu, Shaoguang, Vogelstein, Bert, Kinzler, Kenneth W., Pardoll, Drew M., and Sears, Cynthia L.

Published
2014

5. Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR.

Author

Quanjiang Ji, Liang Zhang, Marcus B. Jones, Fei Sun, Xin Deng, Haihua Liang, Hoonsik Cho, Brugarolas, Pedro, Gao, Yihe N., Peterson, Scott N., Lefu Lan, Bae, Taeok, and Chuan He

Subjects
QUINONE, DIMERIZATION, PATHOGENIC microorganisms, STAPHYLOCOCCUS aureus, PLANT pigments
Abstract

Quinone molecules are intracellular electron-transport carriers, as well as critical intra- and extracellular signals. However, transcriptional regulation of quinone signaling and its molecular basis are poorly understood. Here, we identify a thiol-stress-sensing regulator YodB family transcriptional regulator as a central component of quinone stress response of Staphylococcus aureus, which we have termed the quinone-sensing and response repressor (QsrR). We also identify and confirm an unprecedented quinone-sensing mechanism based on the S-quinonization of the essential residue Cys-5. Structural characterizations of the QsrR-DNA and QsrR-menadione complexes further reveal that the covalent association of menadione directly leads to the release of QsrR from operator DNA following a 10° rigid-body rotation as well as a 9-Å elongation between the dimeric subunits. The molecular level characterization of this quinone-sensing transcriptional regulator provides critical insights into quinone-mediated gene regulation in human pathogens. [ABSTRACT FROM AUTHOR]

Published
2013
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