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Start Over Author "Rosen, Bruce" Journal proceedings of the national academy of sciences of the united states of america
19 results on '"Rosen, Bruce"'

1. Impact of repeated blast exposure on active-duty United States Special Operations Forces.

Author

Gilmore, Natalie, Chieh-En J. Tseng, Maffei, Chiara, Tromly, Samantha L., Deary, Katryna B., McKinney, Isabella R., Kelemen, Jessica N., Healy, Brian C., Hu, Collin G., Ramos-Llordén, Gabriel, Masood, Maryam, Cali, Ryan J., Guo, Jennifer, Belanger, Heather G., Yao, Eveline F., Baxter, Timothy, Fischl, Bruce, Foulkes, Andrea S., Polimeni, Jonathan R., and Rosen, Bruce R.

Subjects
EXPOSURE therapy, POSITRON emission tomography, EXECUTIVE function, DIFFUSION magnetic resonance imaging, PREFRONTAL cortex, TRANSLOCATOR proteins
Abstract

United States (US) Special Operations Forces (SOF) are frequently exposed to explosive blasts in training and combat, but the effects of repeated blast exposure (RBE) on SOF brain health are incompletely understood. Furthermore, there is no diagnostic test to detect brain injury from RBE. As a result, SOF personnel may experience cognitive, physical, and psychological symptoms for which the cause is never identified, and they may return to training or combat during a period of brain vulnerability. In 30 active-duty US SOF, we assessed the relationship between cumulative blast exposure and cognitive performance, psychological health, physical symptoms, blood proteomics, and neuroimaging measures (Connectome structural and diffusion MRI, 7 Tesla functional MRI, [11C]PBR28 translocator protein [TSPO] positron emission tomography [PET]-MRI, and [18F]MK6240 tau PET-MRI), adjusting for age, combat exposure, and blunt head trauma. Higher blast exposure was associated with increased cortical thickness in the left rostral anterior cingulate cortex (rACC), a finding that remained significant after multiple comparison correction. In uncorrected analyses, higher blast exposure was associated with worse health-related quality of life, decreased functional connectivity in the executive control network, decreased TSPO signal in the right rACC, and increased cortical thickness in the right rACC, right insula, and right medial orbitofrontal cortex--nodes of the executive control, salience, and default mode networks. These observations suggest that the rACC may be susceptible to blast overpressure and that a multimodal, network-based diagnostic approach has the potential to detect brain injury associated with RBE in active-duty SOF. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species

Author

Gee, Dylan G, Fetcho, Robert N, Jing, Deqiang, Li, Anfei, Glatt, Charles E, Drysdale, Andrew T, Cohen, Alexandra O, Dellarco, Danielle V, Yang, Rui R, Dale, Anders M, Jernigan, Terry L, Lee, Francis S, Casey, BJ, San Diego, UC, McCabe, Connor, Chang, Linda, Hawaii, U, Akshoomoff, Natacha, Newman, Erik, Core, MRI Acquisition, Ernst, Thomas, Van Zijl, Peter, Kuperman, Joshua, Murray, Sarah, Bloss, Cinnamon, Schork, Nicholas J, Appelbaum, Mark, Gamst, Anthony, Thompson, Wesley, Bartsch, Hauke, Keating, Brian, Amaral, David, Sowell, Elizabeth, Kaufmann, Walter, Mostofsky, Stewart, Ruberry, Erika J, Powers, Alisa, Rosen, Bruce, Kenet, Tal, Frazier, Jean, Kennedy, David, University, Yale, and Gruen, Jeffrey

Subjects
Neurosciences, Brain Disorders, Mental Health, Behavioral and Social Science, Genetics, Pediatric, 2.1 Biological and endogenous factors, Aetiology, Mental health, Adolescent, Adult, Animals, Child, Child, Preschool, Endocannabinoids, Female, Frontal Lobe, Humans, Limbic Lobe, Male, Mice, Mice, Transgenic, Nerve Net, Signal Transduction, Species Specificity, FAAH, frontolimbic, gene x development, anxiety, cross-species, PING Consortium, gene × development
Abstract

Anxiety disorders peak in incidence during adolescence, a developmental window that is marked by dynamic changes in gene expression, endocannabinoid signaling, and frontolimbic circuitry. We tested whether genetic alterations in endocannabinoid signaling related to a common polymorphism in fatty acid amide hydrolase (FAAH), which alters endocannabinoid anandamide (AEA) levels, would impact the development of frontolimbic circuitry implicated in anxiety disorders. In a pediatric imaging sample of over 1,000 3- to 21-y-olds, we show effects of the FAAH genotype specific to frontolimbic connectivity that emerge by ∼12 y of age and are paralleled by changes in anxiety-related behavior. Using a knock-in mouse model of the FAAH polymorphism that controls for genetic and environmental backgrounds, we confirm phenotypic differences in frontoamygdala circuitry and anxiety-related behavior by postnatal day 45 (P45), when AEA levels begin to decrease, and also, at P75 but not before. These results, which converge across species and level of analysis, highlight the importance of underlying developmental neurobiology in the emergence of genetic effects on brain circuitry and function. Moreover, the results have important implications for the identification of risk for disease and precise targeting of treatments to the biological state of the developing brain as a function of developmental changes in gene expression and neural circuit maturation.

Published
2016

3. Multimodal imaging of the self-regulating developing brain

Author

Fjell, Anders M, Walhovd, Kristine Beate, Brown, Timothy T, Kuperman, Joshua M, Chung, Yoonho, Hagler, Donald J, Venkatraman, Vijay, Roddey, J Cooper, Erhart, Matthew, McCabe, Connor, Akshoomoff, Natacha, Amaral, David G, Bloss, Cinnamon S, Libiger, Ondrej, Darst, Burcu F, Schork, Nicholas J, Casey, BJ, Chang, Linda, Ernst, Thomas M, Gruen, Jeffrey R, Kaufmann, Walter E, Kenet, Tal, Frazier, Jean, Murray, Sarah S, Sowell, Elizabeth R, van Zijl, Peter, Mostofsky, Stewart, Jernigan, Terry L, Dale, Anders M, Newman, Erik, Ernst, Thomas, Van Zijl, Peter, Kuperman, Joshua, Murray, Sarah, Bloss, Cinnamon, Appelbaum, Mark, Gamst, Anthony, Thompson, Wesley, Bartsch, Hauke, Keating, Brian, Amaral, David, Sowell, Elizabeth, Kaufmann, Walter, Ruberry, Erika J, Powers, Alisa, Rosen, Bruce, Kennedy, David, and Gruen, Jeffrey

Subjects
Biomedical Imaging, Basic Behavioral and Social Science, Mental Health, Brain Disorders, Neurosciences, Clinical Research, Behavioral and Social Science, Mental health, Neurological, Adolescent, Adult, Brain, Child, Child, Preschool, Humans, Magnetic Resonance Imaging, Young Adult, executive function, cognitive conflict, inhibition, morphometry, Pediatric Imaging, Neurocognition, and Genetics Study
Abstract

Self-regulation refers to the ability to control behavior, cognition, and emotions, and self-regulation failure is related to a range of neuropsychiatric problems. It is poorly understood how structural maturation of the brain brings about the gradual improvement in self-regulation during childhood. In a large-scale multicenter effort, 735 children (4-21 y) underwent structural MRI for quantification of cortical thickness and surface area and diffusion tensor imaging for quantification of the quality of major fiber connections. Brain development was related to a standardized measure of cognitive control (the flanker task from the National Institutes of Health Toolbox), a critical component of self-regulation. Ability to inhibit responses and impose cognitive control increased rapidly during preteen years. Surface area of the anterior cingulate cortex accounted for a significant proportion of the variance in cognitive performance. This finding is intriguing, because characteristics of the anterior cingulum are shown to be related to impulse, attention, and executive problems in neurodevelopmental disorders, indicating a neural foundation for self-regulation abilities along a continuum from normality to pathology. The relationship was strongest in the younger children. Properties of large-fiber connections added to the picture by explaining additional variance in cognitive control. Although cognitive control was related to surface area of the anterior cingulate independently of basic processes of mental speed, the relationship between white matter quality and cognitive control could be fully accounted for by speed. The results underscore the need for integration of different aspects of brain maturation to understand the foundations of cognitive development.

Published
2012

14. Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation

Author

Batchelor, Tracy T., Gerstner, Elizabeth R., Emblem, Kyrre E., Duda, Dan G., Kalpathy-Cramer, Jayashree, Snuderl, Matija, Ancukiewicz, Marek, Polaskova, Pavlina, Pinho, Marco C., Jennings, Dominique, Plotkin, Scott R., Chi, Andrew S., Eichler, April F., Dietrich, Jorg, Hochberg, Fred H., Lu-Emerson, Christine, lafrate, A. John, Ivy, Percy, Rosen, Bruce R., Loeffler, Jay S., Wen, Patrick Y., Sorensen, Greg, and Jain, Rakesh K.

Published
2013

19. Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.

Author

Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Gruen JR, Jernigan TL, Kaufmann WE, Kenet T, Kennedy DN, Kuperman JM, Murray SS, Sowell ER, Rimol LM, Mattingsdal M, Melle I, Agartz I, Andreassen OA, Schork NJ, Dale AM, Weiner M, Aisen P, Petersen R, Jack CR Jr, Jagust W, Trojanowki JQ, Toga AW, Beckett L, Green RC, Saykin AJ, Morris J, Liu E, Montine T, Gamst A, Thomas RG, Donohue M, Walter S, Gessert D, Sather T, Harvey D, Kornak J, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Bandy D, Koeppe RA, Foster N, Reiman EM, Chen K, Mathis C, Cairns NJ, Taylor-Reinwald L, Trojanowki JQ, Shaw L, Lee VM, Korecka M, Crawford K, Neu S, Foroud TM, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder PJ, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider LS, Pawluczyk S, Spann BM, Brewer J, Vanderswag H, Heidebrink JL, Lord JL, Johnson K, Doody RS, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig LS, Bell KL, Morris JC, Ances B, Carroll M, Leon S, Mintun MA, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah RC, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon MJ, Glodzik L, De Santi S, Doraiswamy PM, Petrella JR, Coleman RE, Arnold SE, Karlawish JH, Wolk D, Smith CD, Jicha G, Hardy P, Lopez OL, Oakley M, Simpson DM, Porsteinsson AP, Goldstein BS, Martin K, Makino KM, Ismail MS, Brand C, Mulnard RA, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey AI, Lah JJ, Cellar JS, Burns JM, Anderson HS, Swerdlow RH, Apostolova L, Lu PH, Bartzokis G, Silverman DH, Graff-Radford NR, Parfitt F, Johnson H, Farlow MR, Hake AM, Matthews BR, Herring S, van Dyck CH, Carson RE, MacAvoy MG, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Ging-Yuek, Hsiung R, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam MM, Lipowski K, Wu CK, Johnson N, Sadowsky C, Martinez W, Villena T, Turner RS, Johnson K, Reynolds B, Sperling RA, Johnson KA, Marshall G, Frey M, Yesavage J, Taylor JL, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson AE, Norbash A, Johnson PL, Obisesan TO, Wolday S, Bwayo SK, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, Kittur S, Borrie M, Lee TY, Bartha R, Johnson S, Asthana S, Carlsson CM, Potkin SG, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre DW, Kataki M, Zimmerman EA, Celmins D, Brown AD, Pearlson GD, Blank K, Anderson K, Santulli RB, Schwartz ES, Sink KM, Williamson JD, Garg P, Watkins F, Ott BR, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen HJ, Miller BL, Mintzer J, Longmire CF, Spicer K, Finger E, Rachinsky I, Drost D, Jernigan T, McCabe C, Grant E, Ernst T, Kuperman J, Chung Y, Murray S, Bloss C, Darst B, Pritchett L, Saito A, Amaral D, DiNino M, Eyngorina B, Sowell E, Houston S, Soderberg L, Kaufmann W, van Zijl P, Rizzo-Busack H, Javid M, Mehta N, Ruberry E, Powers A, Rosen B, Gebhard N, Manigan H, Frazier J, Kennedy D, Yakutis L, Hill M, Gruen J, Bosson-Heenan J, and Carlson H

Subjects
Adolescent, Adult, Aged, Brain pathology, Brain Mapping methods, Cohort Studies, Diagnostic Imaging methods, Female, Genome-Wide Association Study, Genomics, Genotype, Humans, Male, Middle Aged, Models, Genetic, Polymorphism, Single Nucleotide, Saccharomyces cerevisiae metabolism, Visual Cortex anatomy & histology, Visual Cortex pathology, Genetic Variation, Phosphoric Diester Hydrolases genetics
Abstract

Visual cortical surface area varies two- to threefold between human individuals, is highly heritable, and has been correlated with visual acuity and visual perception. However, it is still largely unknown what specific genetic and environmental factors contribute to normal variation in the area of visual cortex. To identify SNPs associated with the proportional surface area of visual cortex, we performed a genome-wide association study followed by replication in two independent cohorts. We identified one SNP (rs6116869) that replicated in both cohorts and had genome-wide significant association (P(combined) = 3.2 × 10(-8)). Furthermore, a metaanalysis of imputed SNPs in this genomic region identified a more significantly associated SNP (rs238295; P = 6.5 × 10(-9)) that was in strong linkage disequilibrium with rs6116869. These SNPs are located within 4 kb of the 5' UTR of GPCPD1, glycerophosphocholine phosphodiesterase GDE1 homolog (Saccharomyces cerevisiae), which in humans, is more highly expressed in occipital cortex compared with the remainder of cortex than 99.9% of genes genome-wide. Based on these findings, we conclude that this common genetic variation contributes to the proportional area of human visual cortex. We suggest that identifying genes that contribute to normal cortical architecture provides a first step to understanding genetic mechanisms that underlie visual perception.

Published
2012
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