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Start Over Author "Rubrum A" Journal proceedings of the national academy of sciences of the united states of america
3 results on '"Rubrum A"'

2. Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry

Author

Kim, Jeong-Ki, Kayali, Ghazi, Walker, David, Forrest, Heather L., Ellebedy, Ali H., Griffin, Yolanda S., Rubrum, Adam, Bahgat, Mahmoud M., Kutkat, M. A., Ali, M. A. A., Aldridge, Jerry R., Negovetich, Nicholas J., Krauss, Scott, Webby, Richard J., and Webster, Robert G.

Published
2010

3. Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry.

Author

Jeong-Ki Kim, Kayali, Ghazi, Walker, David, Forrest, Heather L., Ellebedy, Ali H., Griffin, Yolanda S., Rubrum, Adam, Bahgat, Mahmoud M., Kutkat, M. A., Alie, M. A. A., Aldridge, Jerry R., Negovetich, Nicholas J., Krauss, Scott, Wébby, Richard J., and Webster, Robert G.

Subjects
H5N1 Influenza, INFLUENZA vaccines, POULTRY farms, IMMUNE response, PUBLIC health, INFLUENZA prevention
Abstract

In Egypt, efforts to control highly pathogenic H5N1 avian influenza virus in poultry and in humans have failed despite increased biosecurity, quarantine, and vaccination at poultry farms. The ongoing circulation of HP H5N1 avian influenza in Egypt has caused >100 human infections and remains an unresolved threat to veterinary and public health. Here, we describe that the failure of commercially available H5 poultry vaccines in Egypt may be caused in part by the passive transfer of maternal H5N1 antibodies to chicks, inhibiting their immune response to vaccination. We propose that the induction of a protective immune response to H5N1 is suppressed for an extended period in young chickens. This issue, among others, must be resolved and additional steps must be taken before the outbreaks in Egypt can be controlled. [ABSTRACT FROM AUTHOR]

Published
2010
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