1. Programming colloidal bonding using DNA strand-displacement circuitry
- Author
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Xiang Zhou, Xiaowei Chen, Shiyan Xiao, Wenqiang Hua, Liangbin Li, Yunhan Zhang, Fenggang Bian, Ningdong Huang, Miao He, Dongbao Yao, Haojun Liang, and Yijun Guo
- Subjects
endocrine system ,Multidisciplinary ,Materials science ,Protein Conformation ,digestive, oral, and skin physiology ,Temperature ,Metal Nanoparticles ,Nanotechnology ,DNA ,Molecular Dynamics Simulation ,Stimuli Responsive Polymers ,complex mixtures ,Structural transformation ,body regions ,Colloid ,Colloidal gold ,DNA nanotechnology ,Physical Sciences ,Pressure ,Thermodynamics ,Colloids ,Gold ,Base Pairing ,Electronic circuit ,Dna strand displacement - Abstract
As a strategy for regulating entropy, thermal annealing is a commonly adopted approach for controlling dynamic pathways in colloid assembly. By coupling DNA strand-displacement circuits with DNA-functionalized colloid assembly, we developed an enthalpy-mediated strategy for achieving the same goal while working at a constant temperature. Using this tractable approach allows colloidal bonding to be programmed for synchronization with colloid assembly, thereby realizing the optimal programmability of DNA-functionalized colloids. We applied this strategy to conditionally activate colloid assembly and dynamically switch colloid identities by reconfiguring DNA molecular architectures, thereby achieving orderly structural transformations; leveraging the advantage of room-temperature assembly, we used this method to prepare a lattice of temperature-sensitive proteins and gold nanoparticles. This approach bridges two subfields: dynamic DNA nanotechnology and DNA-functionalized colloid programming.
- Published
- 2020