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Start Over Author "Tianye Jia" Journal proceedings of the national academy of sciences of the united states of america
3 results on '"Tianye Jia"'

1. Rsu1 regulates ethanol consumption in Drosophila and humans

Author

Aylin R. Rodan, Tomás Pausu, Anna Cattrell, Sylvane Desrivières, Vincent Frouin, Arun L.W. Bokde, Bernd Ittermann, Jianfeng Feng, Gunter Schumann, Andreas Heinz, Jaana Laitinen, Patricia J. Conrod, Paul F. O'Reilly, Marjo-Riitta Järvelin, Julie L. Kadrmas, Penny A. Gowland, Jean-Luc Martinot, Tobias Banaschewski, Barbara Ruggeri, Rainer Spanagel, Tianye Jia, Herve Lemaitre, Herta Flor, Shamsideen A. Ojelade, Juha Veijola, Mark Lathrop, Fabiana M. Carvalho, Tao Chenyang, Hugh Garavan, Adrian Rothenfluh, Michael N. Smolka, Steven J. Lubbe, Pimphen Charoen, Christian Büchel, and Jürgen Gallinat

Subjects
Nervous system, Adult, Male, Integrins, Adolescent, Alcohol Drinking, RAC1, GTPase, Biology, GTP Phosphohydrolases, Cohort Studies, Surveys and Questionnaires, medicine, Animals, Drosophila Proteins, Humans, Letters, Child, Cytoskeleton, Genes, Dominant, Genetics, Neurons, Multidisciplinary, Polymorphism, Genetic, Ethanol, Cell adhesion molecule, Ventral striatum, Brain, Actin cytoskeleton, Actins, Cell biology, medicine.anatomical_structure, Mushroom bodies, Mutation, Female, Cell Adhesion Molecules, Drosophila Protein, Transcription Factors
Abstract

Alcohol abuse is highly prevalent, but little is understood about the molecular causes. Here, we report that Ras suppressor 1 (Rsu1) affects ethanol consumption in flies and humans. Drosophila lacking Rsu1 show reduced sensitivity to ethanol-induced sedation. We show that Rsu1 is required in the adult nervous system for normal sensitivity and that it acts downstream of the integrin cell adhesion molecule and upstream of the Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase to regulate the actin cytoskeleton. In an ethanol preference assay, global loss of Rsu1 causes high naive preference. In contrast, flies lacking Rsu1 only in the mushroom bodies of the brain show normal naive preference but then fail to acquire ethanol preference like normal flies. Rsu1 is, thus, required in distinct neurons to modulate naive and acquired ethanol preference. In humans, we find that polymorphisms in RSU1 are associated with brain activation in the ventral striatum during reward anticipation in adolescents and alcohol consumption in both adolescents and adults. Together, these data suggest a conserved role for integrin/Rsu1/Rac1/actin signaling in modulating reward-related phenotypes, including ethanol consumption, across phyla.

Published
2015

2. KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.

Author

Schumann, Gunter, O'Reilly, Paul, Bing Xu, Ruggeri, Barbara, Tianye Jia, Desrivières, Sylvane, Yun Liu, Rice, Kenneth M., Shizuo Akira, Satoh, Takashi, Barbieri, Caterina, Sala, Cinzia, Daniela, Toniolo, Baumeister, Sebastian, Teumer, Alexander, Cauchi, Stephane, Loic Yengo, Froguel, Philippe, Clarke, Toni-Kim, and Enroth, Stefan

Subjects
ALCOHOL drinking & health, HUMAN behavior, META-analysis, ALDEHYDE dehydrogenase, CARDIOVASCULAR diseases
Abstract

Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 × 10−12). β-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and implicated in macronutrient preference in humans. We show that brain-specific β-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain. These data suggest that a liver–brain endocrine axis may play an important role in the regulation of alcohol drinking behavior and provide a unique pharmacologic target for reducing alcohol consumption. [ABSTRACT FROM AUTHOR]

Published
2016
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3. Neural basis of reward anticipation and its genetic determinants.

Author

Tianye Jia, Macare, Christine, Desrivières, Sylvane, Gonzalez, Dante A., Chenyang Tao, Xiaoxi Ji, Ruggeri, Barbara, Nees, Frauke, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Conrod, Patricia J., Dove, Rachel, Frouin, Vincent, Gallinat, Jürgen, Garavan, Hugh, Gowland, Penny A., and Heinz, Andreas

Subjects
*BIOLOGICAL neural networks, *DOPAMINE receptors, *ATTENTION-deficit hyperactivity disorder, *DROSOPHILA, *INTELLECTUAL disabilities
Abstract

Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila. Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature. [ABSTRACT FROM AUTHOR]

Published
2016
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