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Your search keyword '"VOUSDEN, KAREN H."' showing total 8 results
Start Over Author "VOUSDEN, KAREN H." Journal proceedings of the national academy of sciences of the united states of america
8 results on '"VOUSDEN, KAREN H."'

8. Induction of p57(KIP2) expression by p73beta.

Author

Balint E, Phillips AC, Kozlov S, Stewart CL, and Vousden KH

Subjects
Animals, Blotting, Western, Cell Line, Cyclin-Dependent Kinase Inhibitor p57, E2F Transcription Factors, Genes, Tumor Suppressor, Genomic Imprinting genetics, Humans, KCNQ Potassium Channels, KCNQ1 Potassium Channel, Mice, Nuclear Proteins genetics, Potassium Channels genetics, RNA, Messenger genetics, RNA, Messenger metabolism, Transcription Factors metabolism, Tumor Cells, Cultured, Tumor Protein p73, Tumor Suppressor Protein p53 metabolism, Tumor Suppressor Proteins, Cell Cycle Proteins, DNA-Binding Proteins metabolism, Nuclear Proteins biosynthesis, Nuclear Proteins metabolism, Potassium Channels, Voltage-Gated, Up-Regulation
Abstract

The p53-related protein p73 has many functions similar to that of p53 including the ability to induce cell-cycle arrest and apoptosis. Both p53 and p73 function as transcription factors, and p73 activates expression of many genes that also are regulated by p53. Despite their similarities, it is evident that p53 and p73 are not interchangeable functionally, with p73 playing a role in normal growth and development that is not shared by p53. In this paper we describe the ability of p73beta but not p53 to activate expression of the cyclin-dependent kinase inhibitor p57(KIP) and KvLQT1, two genes that are coregulated in an imprinted region of the genome. Our results suggest that p73 may regulate expression of genes through mechanisms that are not shared by p53, potentially explaining the different contributions of p53 and p73 to normal development.

Published
2002
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