9 results on '"Yu Ding"'
Search Results
2. Real-time tracking of electron transfer at catalytically active interfaces in lithium-ion batteries.
- Author
-
Hongsen Li, Zhengqiang Hu, Fengkai Zuo, Yuhao Li, Minhui Liu, Hengjun Liu, Yadong Li, Qiang Li, Yu Ding, Yaqun Wang, Yue Zhu, Guihua Yu, and Maier, Joachim
- Abstract
Transition metals and related compounds are known to exhibit high catalytic activities in various electrochemical reactions thanks to their intriguing electronic structures. What is lesser known is their unique role in storing and transferring electrons in battery electrodes which undergo additional solid-state conversion reactions and exhibit substantially large extra capacities. Here, a full dynamic picture depicting the generation and evolution of electrochemical interfaces in the presence of metallic nanoparticles is revealed in a model CoCO
3 /Li battery via an in situ magnetometry technique. Beyond the conventional reduction to a Li2 CO3 /Co mixture under battery operation, further decomposition of Li2 CO3 is realized by releasing interfacially stored electrons from its adjacent Co nanoparticles, whose subtle variation in the electronic structure during this charge transfer process has been monitored in real time. The findings in this work may not only inspire future development of advanced electrode materials for next-generation energy storage devices but also open up opportunities in achieving in situ monitoring of important electrocatalytic processes in many energy conversion and storage systems. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
3. Electrochemical interfacial catalysis in Co-based battery electrodes involving spin-polarized electron transfer.
- Author
-
Fengkai Zuo, Hao Zhang, Yu Ding, Yongshuai Liu, Yuhao Li, Hengjun Liu, Fangchao Gu, Qiang Li, Yaqun Wang, Yue Zhu, Hongsen Li, and Guihua Yu
- Subjects
CHARGE exchange ,MELT spinning ,ELECTRODES ,CATALYSIS ,DENSITY functional theory ,ELECTRONIC structure - Abstract
Interfacial catalysis occurs ubiquitously in electrochemical systems, such as batteries, fuel cells, and photocatalytic devices. Frequently, in such a system, the electrode material evolves dynamically at different operating voltages, and this electrochemically driven transformation usually dictates the catalytic reactivity of the material and ultimately the electrochemical performance of the device. Despite the importance of the process, comprehension of the underlying structural and compositional evolutions of the electrode material with direct visualization and quantification is still a significant challenge. In this work, we demonstrate a protocol for studying the dynamic evolution of the electrode material under electrochemical processes by integrating microscopic and spectroscopic analyses, operando magnetometry techniques, and density functional theory calculations. The presented methodology provides a real-time picture of the chemical, physical, and electronic structures of the material and its link to the electrochemical performance. Using Co(OH)2 as a prototype battery electrode and by monitoring the Co metal center under different applied voltages, we show that before a well-known catalytic reaction proceeds, an interfacial storage process occurs at the metallic Co nanoparticles/LiOH interface due to injection of spin-polarized electrons. Subsequently, the metallic Co nanoparticles act as catalytic activation centers and promote LiOH decomposition by transferring these interfacially residing electrons. Most intriguingly, at the LiOH decomposition potential, electronic structure of the metallic Co nanoparticles involving spin-polarized electrons transfer has been shown to exhibit a dynamic variation. This work illustrates a viable approach to access key information inside interfacial catalytic processes and provides useful insights in controlling complex interfaces for wide-ranging electrochemical systems. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
4. Odd viscosity-induced Hall-like transport of an active chiral fluid
- Author
-
Xin Lou, Qing Yang, Yu Ding, Peng Liu, Ke Chen, Xin Zhou, Fangfu Ye, Rudolf Podgornik, and Mingcheng Yang
- Subjects
Multidisciplinary - Abstract
Broken time-reversal and parity symmetries in active spinner fluids imply a nondissipative “odd viscosity,” engendering phenomena unattainable in traditional passive or active fluids. Here we show that the odd viscosity itself can lead to a Hall-like transport when the active chiral fluid flows through a quenched matrix of obstacles, reminiscent of the anomalous Hall effect. The Hall-like velocity depends significantly on the spinner activity and longitudinal flow due to the interplay between odd viscosity and spinner–obstacle collisions. Our findings underscore the importance of odd viscosity in active chiral matter and elucidate its essential role in the anomalous Hall-like effect.
- Published
- 2023
5. Cspg4high microglia contribute to microgliosis during neurodegeneration.
- Author
-
Ya-jing Liu, Yu Ding, Yan-qing Yin, Hui Xiao, Gang Hu, and Jia-wei Zhou
- Subjects
- *
CHONDROITIN sulfate proteoglycan , *MICROGLIA , *PARKINSON'S disease , *ALZHEIMER'S disease , *NEURODEGENERATION - Abstract
Microglia play a critical role in the pathogenic process of neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease (AD). Upon pathological stimulation, microglia are converted from a surveillant to an overactivated phenotype. However, the molecular characters of proliferating microglia and their contributions to the pathogenesis of neurodegeneration remain unclear. Here, we identify chondroitin sulfate proteoglycan 4 (Cspg4, also known as neural/glial antigen 2)-expressing microglia as a specific subset of microglia with proliferative capability during neurodegeneration. We found that the percentage of Cspg4+ microglia was increased in mouse models of PD. The transcriptomic analysis of Cspg4+ microglia revealed that the subcluster Cspg4high microglia displayed a unique transcriptomic signature, which was characterized by the enrichment of orthologous cell cycle genes and a lower expression of genes responsible for neuroinflammation and phagocytosis. Their gene signatures were also distinct from that of known disease-associated microglia. The proliferation of quiescent Cspg4high microglia was evoked by pathological a-synuclein. Following the transplantation in the adult brain with the depletion of endogenous microglia, Cspg4high microglia grafts showed higher survival rates than their Cspg4- counterparts. Consistently, Cspg4high microglia were detected in the brain of AD patients and displayed the expansion in animal models of AD. These findings suggest that Cspg4high microglia are one of the origins of microgliosis during neurodegeneration and may open up a avenue for the treatment of neurodegenerative diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
6. Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide
- Author
-
Haikun Song, Cen Wang, Chenggang Zhu, Ziying Wang, Huiya Yang, Peng Wu, Xiaotian Cui, Juan Botas, Yongjun Dang, Yu Ding, Yiyan Fei, and Boxun Lu
- Subjects
Desonide ,Disease Models, Animal ,Huntingtin Protein ,Mice ,Multidisciplinary ,Huntington Disease ,Protein Stability ,Mutation ,Animals ,Mice, Transgenic - Abstract
Identifying inhibitors of pathogenic proteins is the major strategy of targeted drug discoveries. This strategy meets challenges in targeting neurodegenerative disorders such as Huntington’s disease (HD), which is mainly caused by the mutant huntingtin protein (mHTT), an “undruggable” pathogenic protein with unknown functions. We hypothesized that some of the chemical binders of mHTT may change its conformation and/or stability to suppress its downstream toxicity, functioning similarly to an “inhibitor” under a broader definition. We identified 21 potential mHTT selective binders through a small-molecule microarray–based screening. We further tested these compounds using secondary phenotypic screens for their effects on mHTT-induced toxicity and revealed four potential mHTT-binding compounds that may rescue HD-relevant phenotypes. Among them, a Food and Drug Administration–approved drug, desonide, was capable of suppressing mHTT toxicity in HD cellular and animal models by destabilizing mHTT through enhancing its polyubiquitination at the K6 site. Our study reveals the therapeutic potential of desonide for HD treatment and provides the proof of principle for a drug discovery pipeline: target-binder screens followed by phenotypic validation and mechanistic studies.
- Published
- 2022
7. Odd viscosity-induced Hall-like transport of an active chiral fluid.
- Author
-
Xin Lou, Qing Yang, Yu Ding, Peng Liu, Ke Chen, Xin Zhou, Fangfu Ye, Podgornik, Rudolf, and Mingcheng Yang
- Subjects
BIOLOGICAL transport ,FLUID flow ,FLUIDS ,VISCOSITY ,COLLECTIVE behavior - Abstract
Broken time-reversal and parity symmetries in active spinner fluids imply a nondissipative “odd viscosity,” engendering phenomena unattainable in traditional passive or active fluids. Here we show that the odd viscosity itself can lead to a Hall-like transport when the active chiral fluid flows through a quenched matrix of obstacles, reminiscent of the anomalousHall effect.TheHall-like velocity depends significantly on the spinner activity and longitudinal flow due to the interplay between odd viscosity and spinner– obstacle collisions. Our findings underscore the importance of odd viscosity in active chiral matter and elucidate its essential role in the anomalous Hall-like effect. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
8. Transfected Human Liver Cytochrome P-450 Hydroxylates Vitamin D Analogs at Different Side-Chain Positions
- Author
-
Guo, Yu-Ding, Strugnell, Stephen, Back, Donald W., and Jones, Glenville
- Published
- 1993
9. Transfected human liver cytochrome P-450 hydroxylates vitamin D analogs at different side-chain positions
- Author
-
Stephen Strugnell, Donald W. Back, Yu-Ding Guo, and Glenville Jones
- Subjects
Vitamin ,Carcinoma, Hepatocellular ,Cytochrome ,Molecular Sequence Data ,Mitochondria, Liver ,Hydroxylation ,Kidney ,Transfection ,Polymerase Chain Reaction ,Mass Spectrometry ,Cell Line ,Substrate Specificity ,chemistry.chemical_compound ,Cytochrome P-450 Enzyme System ,Complementary DNA ,Chlorocebus aethiops ,Vitamin D and neurology ,Tumor Cells, Cultured ,Animals ,Humans ,RNA, Messenger ,Vitamin D ,Chromatography, High Pressure Liquid ,Multidisciplinary ,biology ,Base Sequence ,cDNA library ,Liver Neoplasms ,Cytochrome P450 ,Molecular biology ,Recombinant Proteins ,Rats ,chemistry ,Biochemistry ,Oligodeoxyribonucleotides ,Steroid Hydroxylases ,biology.protein ,Cholestanetriol 26-Monooxygenase ,RNA ,Cholecalciferol ,Poly A ,Research Article - Abstract
A full-length cDNA for the human liver mitochondrial cytochrome P-450 CYP27 was cloned from a human hepatoma HepG2 cDNA library and then subcloned into the mammalian expression vector pSG5. When CYP27 cDNA was transfected into COS-1 transformed monkey kidney cells along with adrenodoxin cDNA, transfected cells revealed a 10- to 20-fold higher vitamin D3-25-hydroxylase activity than nontransfected cells. Transfected cells were capable of 25-hydroxylation of vitamin D3, 1 alpha-hydroxyvitamin D3 and 1 alpha-hydroxydihydrotachysterol3. In each case they also showed the ability to 26(27)-hydroxylate the cholesterol-like (D3) side chain. The relative rates of 25- and 26(27)-hydroxylation of 1 alpha-hydroxyvitamin D3 approximately mimicked the ratio of products observed in HepG2 cells. Vitamin D2 and 1 alpha-hydroxyvitamin D2, both with the ergosterol-like side chain, were 24- and 26(27)-hydroxylated by CYP27. The rate of side-chain 24-, 25-, or 26(27)-hydroxylation was greater for 1 alpha-hydroxylated vitamin D analogs than for their nonhydroxylated counterparts. We conclude that CYP27 is capable of 24-, 25-, and 26(27)-hydroxylation of vitamin D analogs and that the nature of products is partially dictated by the side chain of the substrate. This work has revealed that the cytochrome P-450 CYP27 may be important in the metabolism of vitamin D analogs used as drugs.
- Published
- 1993
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.