1. Cell Factories for Industrial Production Processes: Current Issues and Emerging Solutions
- Author
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Irene Hjorth Jacobsen, José L. Martínez, Alessandra Procentese, and Clara Navarrete
- Subjects
biomass pretreatment ,Yarrowia lipolytica ,0106 biological sciences ,Cell factory ,Trichosporon oleaginosus ,Computer science ,Industrial production ,Bioengineering ,lcsh:Chemical technology ,01 natural sciences ,Biotechnological process ,lcsh:Chemistry ,Metabolic engineering ,Bioreactor configuration ,03 medical and health sciences ,010608 biotechnology ,Bioreactor ,Chemical Engineering (miscellaneous) ,lcsh:TP1-1185 ,lignocellulosic biomass ,030304 developmental biology ,Lignocellulosic inhibitors ,0303 health sciences ,biology ,Biomass pretreatment ,Process Chemistry and Technology ,Ustilago cynodontis ,Yarrowia ,lignocellulosic inhibitors ,biology.organism_classification ,Lignocellulosic biomass ,Debraryomyces hansenii ,lcsh:QD1-999 ,Biochemical engineering ,cell factory - Abstract
Despite all the progresses made by metabolic engineering, still only a few biotechnological processes are running at an industrial level. In order to boost the biotechnological sector, integration strategies as well as long-term views are needed. The aim of the present review is to identify the main drawbacks in biotechnological processes, and to propose possible solutions to overcome the issues in question. Novel cell factories and bioreactor design are discussed as possible solutions. In particular, the following microorganisms: Yarrowia lipolytica, Trichosporon oleaginosus, Ustilago cynodontis, Debaryomyces hansenii along with sequential bioreactor configurations are presented as possible cell factories and bioreactor design solutions, respectively.
- Published
- 2020
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