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Nasal polyps are soft, pink or pearl white outgrowths usually connected with nasal mucosa by flaccid crus. A histological image of nasal polyps indicates significant differences in particular cases. Because of the variety of nasal polyps, the choice of proper laryngological treatment is very difficult. Difficulties in treatment are due to the lack of consensus among physicians regarding the etiopathogenesis of nasal polyps. Probably etiopathogenesis of nasal polyps is not homogeneous and polyps' formation is influenced by many coexisting mechanisms. [ABSTRACT FROM AUTHOR]

Introduction: Cystic fibrosis (CF) is inherited, metabolic, multisystem disease with various clinical symptoms. In the airways neutrophilic inflammation and increased levels of neutrophil elastase (NE) are observed even in young children. The method of electrophoretic mobility of cell nuclei (EMN) is a way of assessment cell maturity. Observed distorted nuclei mobility is mostly dependent on chromatin distribution and remodeling. Purpose: To evaluate the EMN index in buccal cells collected from CF patients. Materials and methods: The study was conducted in the group of 15 CF patients aged 5-26 years. Results: In the healthy subjects we have observed that the lowest EMN index values were reach around 2 year of life (7.6 ± 3.1) and in the late senescence (8.5 ± 2.5) with the peak values around 16-21 years (61.4 ± 2.5). The results differed significantly from the healthy controls. Conclusion: EMN index in CF buccal cells may be a simple method to quickly assess the chromatin remodeling. [ABSTRACT FROM AUTHOR]