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Objective: To prepare acetazolamide extended-release pellets by extrusion-spheronization process and assess its release behavior in vitro. Methods: Ion exchange chromatography was applied to determine the content of sodium lauryl sulfate as the functional excipient in the formulation of the reference listed drug. According to the formulation analysis of the reference listed drug, the water-insoluble microcrystalline cellulose was used as the matrix material of extended-release pellets, and the hydroxy propyl cellulose aqueous solution was used as the adhesive excipient. Through extrusion-spheronization process, the pellets became dense spheroids, so as to slowly release the drug. When viscosity of damp mass and release curves of capsules were considered as the main indexes, acetazolamide extended-release pellets were prepared by extrusion-spheronization process, dried and filled into capsules. The release curves of the self-made preparation and the reference drug in pH1.2 hydrochloric acid solution, pH 4.5 acetate buffer, pH 6.8 phosphate buffer and water were determined respectively. And the similarity factor (f) method was used to compare the similarity of the release curves between two formulations. Results: The types and amounts of excipients of the self-made preparation and the reference listed drug are basically the same. The preparation process of the pellets is relatively simple. And drugs can be released slowly from the self-made preparation in four different media. The release curve trends of the self-made preparation and the reference listed drug in four different media were basically similar, and the similarity factor (f) values of the release curve between two formulations were all above 50. Conclusion: The release behavior in vitro of the self-made preparation was consistent with that of the reference listed drug. [ABSTRACT FROM AUTHOR]

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To observe the performance of human epididymis protein 4 (HE4), aldehyde dehydrogenase 1 (ALDH1) and adhesion molecule CD44 in differential diagnosis of benign and malignant ovarian tumors. 100 patients with ovarian carcinoma and 100 patients with benign ovarian tumor who were admitted to the hospital from January 2020 to May 2022 were selected, and included in the malignant group and the benign group. At the same time, 100 healthy women were selected as the control group. The expression of HE4 and ALDH1 in serum and CD44 in tissues of the three groups was compared. The value of the three parameters in differential diagnosis of benign and malignant ovarian tumors was analyzed using the receiver operating characteristic (ROC) curve. The levels of HE4 and ALDH1, and CD44 positive expression rate decreased in order from the malignant group, the benign group to the control group (P<0.05). For the malignant group, the levels of HE4 and ALDH1, and CD44 positive expression rate were higher in patients with clinical stage III-IV and lymph node metastasis than those with clinical stage I-II and without lymph node metastasis (P<0.05). Spesrman correlation analysis found that the levels of HE4 and ALDH1, and CD44 positive expression rate were positively correlated with clinical stage and lymph node metastasis in patients with ovarian carcinoma (P<0.05). ROC curve analysis results showed that the area under the curve (AUC) values of HE4, ALDH1, and CD44 in differential diagnosis of benign and malignant ovarian tumors were 0.837, 0.768, and 0.610, respectively. The AUC and sensitivity of combined diagnosis with the three indicators were higher than those of single diagnosis (P<0.05). The expression of HE4 and ALDH1 in serum and CD44 in tissues of patients with malignant ovarian tumors is high. The expression level is closely related to clinical stage and lymph node metastasis of ovarian carcinoma. The combination of HE4, ALDH1 and CD44 is of high value in the differential diagnosis of benign and malignant ovarian tumors. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Exploration and analysis of factors influencing pain and recovery of shoulder joint function in middle-aged and elderly patients with shoulder pain. Methods: Using a convenience sampling method, 2010 middle-aged and elderly patients who attended our outpatient clinic between September 2020 to September 2022 were randomly selected as subjects for screening, review, confirmation, and follow-up. The collected information was also analyzed by univariate and multifactorial logistic regression analysis for pain and shoulder function recovery. Results: Univariate analysis showed that age (x²=15.274, P<0.001), gender (x²=10.401, P=0.001), disease duration (x²-16.410, P<0.001) and whether functional exercise was performed (x²=6.293, P=0.012) were the main factors affecting the recovery of shoulder function in middle-aged and elderly patients with shoulder pain; age ≥70 years (OR=1.292, 95% CI 0.953-1.750), female (OR=1.672, 95%CI 1.348-2.074), duration of disease >1 month (OR=1.470, 95%CI 1.021-2.116) and no functional exercise (OR=1.844, 95%CI 1.175-2.894) were the independent risk factors affecting the functional recovery of shoulder joint in middle-aged and elderly patients with shoulder pain. independent risk factors for functional recovery of the shoulder joint in middle-aged and elderly patients. Conclusion: Age 70 years, female, disease duration >1 month and failure to perform functional exercise are independent risk factors affecting the recovery of shoulder joint function in middle-aged and elderly patients with shoulder pain. Early and rapid screening of high-risk patients based on these factors and early administration of reasonable and effective rehabilitation measures can significantly improve the prognosis of shoulder joint function in patients with shoulder pain. [ABSTRACT FROM AUTHOR]

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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To explore the correlation of disease perception status, hope level and quality of life in patients with liver cancer. 126 patients with liver cancer in our hospital from October 2017 to October 2020 were selected. The perception status of patients was assessed by the brief illness perception questionnaire (BIPQ), the hope level was assessed by Herth hope index (HHI), and the quality of life was assessed by the 36-item medical outcomes study short-form (SF-36). The relationship between BIPQ, HHI scores and clinical data of liver cancer patients was analyzed. According to the BIPQ scores of patients with liver cancer, they were divided into BIPQ≥ 48 scores group and BIPQ＜48 scores group. According to HHI scores, they were divided into HHI≥ 24 scores group and HHI＜ 24 scores group. The SF-36 scores of patients with different BIPQ and HHI scores were compared, and the correlation between BIPQ, HHI scores and SF-36 scores in patients with liver cancer. were analyzed. The BIPQ score of patients with educational years <9 years, clinical stage III and combined with liver cirrhosis were higher than those of patients with educational years ≥ 9 years, clinical stage I-II and patients without liver cirrhosis. And the HHI score of patients with educational years <9 years, clinical stage III, family monthly income <3000 yuan and combined with liver cirrhosis were lower than those of patients with educational years ≥ 9 years, clinical stage I-II, family monthly income ≥ 3000 yuan and patients without liver cirrhosis (P<0.05). The social function, physical function, mental health, physical pain, energy, physical role function, emotional role function and overall health scores of the BIPQ≥ 48 scores group were lower than those in the BIPQ<48 scores group, and the scores of the HHI≥ 24 scores group were higher than those in the HHI<24 scores group (P<0.05). The BIPQ score was negatively correlated with the SF-36 dimension scores, and the HHI score was positively correlated with the SF-36 dimension scores (P<0.05). The disease perception status and hope level of liver cancer patients are affected by many factors, and they are closely related to the quality of life. The lower the negative perception of disease and the higher the hope level of patients with liver cancer, the better the quality of life. [ABSTRACT FROM AUTHOR]

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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the effects of Xiangpi Shengji ointment on inflammatory factors, p38/MK2 signaling pathway and the expression of vascular endothelial growth factor(VEGF) and basic fibroblast growth factor (bFGF) in wound tissue of rats after anal fistula operation. Methods: Sixty male SD rats were selected, they were randomly divided into Xiangpi Shengji ointment group, model group and sham operation group with 20 rats in each group. The wound models of the two groups were made after anal fistula operation, and treated with Xiangpi Shengji ointment and common dressing change respectively. The sham operation group was treated with normal saline after wound construction. Results: The wound healing rate and wound edema score were calculated on 3 d, 7 d and 14 d after treatment, the levels of serum interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) on the 14 d after treatment and the expressions of VEGF, bFGF, p38, MK2, phosphorylated p38 (p-p38) and phosphorylated MK2 (p-MK2) on the 3 d and 14th day after treatment were compared. The wound healing rate of the Xiangpi Shengji ointment group was higher than that of the model group, but lower than that of the sham operation group (P<0.05). The wound edema score of the sham operation group was lower than that of the Xiangpi Shengji ointment group, and the Xiangpi Shengji ointment group was lower than that of the model group (P<0.05). 14 d after treatment, the levels of serum IL-1, IL-6 and TNF-α in the Xiangpi Shengji ointment group were lower than those in the model group, but higher than those in the sham operation group (P<0.05). 14 d after treatment, the levels of VEGF and bFGF in Xiangpi Shengji ointment group were higher than those in model group, but lower than those in sham operation group (P<0.05). 14 d after treatment, the protein levels of p38 and MK2 in Xiangpi Shengji ointment group were lower than those in the model group, but higher than those in the sham operation group, and the protein levels of p-p38, p-MK2 in Xiangpi Shengji ointment group were higher than those in the model group, but lower than those in the sham operation group(P<0.05). Conclusion: Xiangpi Shengji ointment can reduce the degree of postoperative wound edema and promote wound healing. The main mechanism may be that Xiangpi Shengji ointment can reduce the level of serum inflammatory factors, inhibit p38/MK2 signaling pathway, and promote the expression of VEGF and bFGF. [ABSTRACT FROM AUTHOR]

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To study Analysis of valsartan hydrochlorothiazide in patients with hypertension with heart failure Angiotensin Ⅱ (Ang Ⅱ) and amino terminal brain natriuretic peptide precursor (NT - ProBNP) and connective tissue growth factor (CTGF). 113 patients ofHypertension complicated with heart failurewhoreceived therapy fromMarch 2016 to March 2019wereselected as research objects. The control group was treated with Benazepril, while the observation group was treated withValsartan hydrochlorothiazide. Then clinical curative effect, Ang Ⅱ, NT - ProBNP and CTGF, left ventricular ejection fraction (LVEF), left ventricular end systolic diameter (LVESd), left ventricular end-diastolic diameter (LVEDd), systolic blood pressure (SBP), diastolic blood pressure (DBP) level changes and complicationswere compared. After treatment, the total effective rates of the two groups were 92.98% and 73.21%, respectively, with significant differences. Before the treatment, two groups of Ang Ⅱ, NT - ProBNP and CTGF levels had no significant difference (P>0.05); After treatment, two groups of Ang Ⅱ, NT - ProBNP and CTGF levels were significantly improved, and the observation group were lower than control group (P<0.05); Before treatment, there was no significant difference in cardiac function between the two groups (P>0.05). After treatment, cardiac function levels in both groups were significantly improved, and LVEF and LVESd in the observation group were higher than those in the control group, while LVESd and LVEDd were lower than those in the control group (P<0.05). Before treatment, there was no significant difference in blood pressure between the two groups (P>0.05). After treatment, blood pressure levels in both groups were significantly improved, and SBP and DBP levels in the observation group were significantly lower than those in the control group (P<0.05). The total incidence of complications in the two groups was 7.02% and 10.71%, respectively, with no significant difference (P>0.05). Used in heart failure patients with hypertension combined valsartan hydrochlorothiazide adjuvant therapy effect is remarkable, which can effectively improve the patients' heart function, Ang Ⅱ, NT - ProBNP and CTGF level. [ABSTRACT FROM AUTHOR]

To study the pathogenesis of high thyroxine induced atrial fibrillation and renin-angiotension system (RAS). The model of hyperthyroid atrial fibrillation was made by injecting levothyroxine into abdominal cavity of rabbits, at the same time, irbesartan was infused into the stomach through gastric tube, and drug intervention was carried out in the left atrial myocyte culture of suckling rabbits. The induction rate of atrial fibrillation and apoptosis of left atrial myocytes were measured, RAS related cytokines and apoptotic protein expression were measured. The induced rate of atrial fibrillation in the withdrawal group, irbesartan group and control group was lower than that in the continuous administration group (P<0.05). The cardiomyocyte apoptosis rate, relative expression of ACE mRNA, ACE plasma concentration, expression amount, AngⅡ plasma concentration and expression amount in the with drawal group, the continuous administration group and the irbesartan group were higher than those in the control group, and those in the continuous administration group were higher than those in the withdrawal group and the irbesartan group (P<0.05). The relative expression of PARP and caspase3 in the withdrawal group, the continuous administration group and the irbesartan group were higher than those in the control group, and those in the continuous administration group were higher than those in the withdrawal group and the irbesartan group (P<0.05). The apoptosis rate of left atrial myocytes in AngⅡ group was higher than that in control group and thyroxine group after drug intervention (P<0.05). One of the pathogenesis of high thyroxine induced atrial fibrillation may be that it indirectly overactivates RAS, increases the expression of AngⅡin circulation and tissue, the latter induces apoptosis of atrial myocytes and electrical anatomical remodeling of left atrium. [ABSTRACT FROM AUTHOR]

Objective: To analyze the clinical efficacy of initial low-dose methimazole in the treatment of patients with Graves' hyperthyroidism and its effect on the thyroid function and visfutin, TNF-α and IL-6 levels. Methods: 125 patients with Graves' hyperthyroidism who were diagnosed in our hospital from January 2017 to June 20 18 were selected and divided into two groups according to the admission number. 63 cases in the control group were given methimazole 15 mg/time, twice a day. 62 cases in the study group were given methimazole 10 mg/time, twice a day, and both groups were treated continuously for 6 months. The total effective rate, changes of thyroid function and the levels of Visfatin, TNF-α, IL-6 of before and after treatment were compared between two groups. Results: After treatment, the total effective rate of study group was significantly higher than that of the control group (90.32% vs. 77.78%, P<0.05). After treatment, the levels of thyroid function indexes of FT3 and FT4 in the two groups were significantly decreased, while the sTSH level was significantly increased, and the above indicators in the study group improved more significant than the control group (P<0.0 5) . After treatment, the levels of serum Visfatin, TNF-α, and IL-6 decreased in the two groups were significantly lower than those before treatment, and the above indexes of the study group were more significantly lower than the control group (P<0.05). Conclusions: The initial low-dose (1 mg/time) methimazole was significantly better than methimazole 15 mg/treatment in the treatment of Graves' disease, which may be related to effectively improve the thyroid function of patients and the levels of inflammatory factors such as serum Visfutin, TNF-α, IL-6. [ABSTRACT FROM AUTHOR]

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Objective: To investigate the clinical efficacy and safety of zoledronic acid injection combined with bone peptide injection in the treatment of postmenopausal osteoporosis. Methods: 100 cases of patients with postmenopausal osteoporosis admitted to our hospital fromJanuary 2014 to January 2018 were randomly divided into two groups. The control group was given zoledronic acid injection 5 mg once, while the observation group was given bone peptide injection 30 mg once a day on the basis of the control group. After 6 months of treatment, the changes of bone metabolism indexes (serum bone specific alkaline phosphatase (BAP), parathyroid hormone (PTH), blood phosphorus (P), blood calcium (Ca) and alkaline phosphatase (ALP), bone turnover indexes (OC) and collagen type I cross-linked C-terminal peptide (CTX-1) and adverse reactions were detected and compared between the two groups before and after treatment. Results: After treatment, the total effective rate of observation group was significantly higher than that of the control group(P< 0.05); the serum ALP, PTH and BAP of both groups were significantly lower than those before treatment(P<0.05), and the above indexes of observation group were significantly lower than those of the control group(P<0.05); the OC of the two groups were significantly higher than before treatment(P<0.05), the CTX-1 was significantly lower than before treatment(P<0.05). The improvement of bone turnover index in the observation group was more significant than that in the control group (P<0.05). The incidence of adverse reactions in the observation group was 8%(4/50), which was significantly lower than that in the control group [18.00%(9/50)] (P<0.05). Conclusions: Zoledronic acid injection combined with bone peptide injection is significantly effective than zoledronic acid injection alone in the treatment of postmenopausal osteoporosis, which can significantly improve bone metabolismand bone turnover with higher safety. [ABSTRACT FROM AUTHOR]

Paraquat (Paraquat, PQ) is highly toxic to humans and animals, which can cause irreversible diffuse fibrosis in lung tissue, and eventually lead to death due to respiratory failure. Polydatin (Polydatin, PD) is separated from the dried rhizome of Polygonum cuspidatum in a stilbene organic compound, is also the main componentexert pharmacological effects, antioxidation, antitumor, anti inflammation, free radical scavenging, reducing pulmonary fibrosis and other rich pharmacological activity. Recent studies have shown that the mechanism of PD in treating PQ poisoning pulmonary fibrosis can be summarized as antioxidant stress, regulating the imbalance of cytokine network regulation and imbalance of matrix metalloproteinase (MMPs) / tissue inhibitor of metalloproteinase (TIMPs). In this paper, the research progress on the mechanismof PD anti PQ poisoning pulmonary fibrosis is reviewed. [ABSTRACT FROM AUTHOR]

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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Using gene chip technology to study the differences ofhepatitis B virus(HBV) drug resistance gene between Han and Uygur patients in Ili Prefecture. Methods: Selected 50 cases of Han patients and 50 cases of Uygur patients who with chronic HBV infection treated in our hospital from January 2014 to December 2015, they were diagnosed with natural HBV drug resistance gene (anti Nucleotide drugs)by gene chip technology, then observed the characteristics of HBV drug resistance genotypes, and the status of drug resistant mutations sites to Nucleotide drugs. Results: The HBV drug resistance genotypes of Han patients were focus on B-type and C-type, and the C-type was the predominant genotype, while D-type was the most genotype in Uygur patients, the differences of each genotype in two groups was statistically significant (P<0.05). Han patients was mutated significantly at rt204 site, while the Uighur patients was mutated significantly at rtn236t and rta181v/t+rtn236t sites. Conclusion: The HBV drug resistance genotypes and mutations sites are significantly different between Han and Uygur patients with natural HBV drug resistance gene in Ili Prefecture of Xinjiang,we can screen the the mutation targets through the gene chip technology and select the appropriate sensitive drug. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between hyperlipidemia and colorectal polyps, and to analyze the risk factors associated with the occurrence of colorectal polyps. Methods: Thelevels of TG, TC and LDL-C of 160 patients with colorectal polyps and 153 controls were detected. The serum lipids between colorectal polyps group and control group, of colorectal polyps with different pathological type, of adenomatous polyps with different location, of colorectal polyps of different gender, and different size of polyps were compared. Results: The incidence of hyperlipidemia in colorectal polyps group was higher than that in the control group, The incidence of hyperlipidemia in male colorectal polyps group was higher than that in female, and the differences were both statistically significant( P＜0.05). There were no significant differences in serum TC, TG and LDL-C between different pathological types of polyp group (P >0.05). The hyperlipidemia incidence of the left colon and rectum polyp group was higher than that of the right colon group. The incidence of colon polyps of overweight person (BMI ≥ 24 kg/m2) was higher than the normal high of BMI, and the incidence rate of greater than 1cm was significantly higher than that of less than 1 cm(P＜0.05). Conclusions: Hyperlipidemia, obesity and male are high risk factors of colorectal polyps, and that the size and the location of polyps are closely related with the incidence of hyperlipidemia. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Analyze the difference of clinical onset and prognosis in patients with idiopathic dilated cardiomyopathy with or without gene mutations. Methods: A total of 115 IDCM patients were enrolled from January 2011 to September 2014. All patients were subjected to targeted next-generation sequencing to identify whether a pathological mutation existed. These IDCM patients were divided into 2 groups: the mutant group and non-mutant group. All patients were followed up with telephone contact. The clinical data and end points were compared. Results: Comparisons between these two groups showed no significant difference in baseline characteristics such as gender, age of symptom onset, blood pressure, and diabetes; assistant examination data such as left ventricular ejection fraction(LVEF), left ventricular diastolic diameters(LVDD), QRS-T angles and serum creatinine level; pharmacotherapy and device implantation; and prognosis including re-hospitalization and all-cause mortality. Factors, such as gender, smoking, diabetes, device implantation and mutation, were analyzed by the method of Cox Regression Analysis. It showed that these factors did not influence their prognosis.Conclusion: There is no significant difference in clinical data and end points between the two groups. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Tumor microenvironment(TME) of pancreatic ductal adenocarcinoma(PDAC) plays an important role in tumorigenesis, progression and invasion. It has a similar structure and components with other malignancy. Meanwhile it is characterized as massive extracellular matrix and plenty of actived pancreatic stellate cells which produce a dense fibrous storm which forms a hypovascular solid tumor. Broad repertoire of immune cells including both adaptive and innate cell types are also present in the PDAC tumor microenvironment, which are imbalance in either quantity or function. These tumor infiltrating immune cells have been implicated in tumor progression, invasion and metastasis as well as Immune tolerance and escape. This review summarizes the recent researches of PDAC microenvironmen. [ABSTRACT FROM AUTHOR]

CD4+CD25+Foxp3+ regulatory T cells can effectively inhibit the immune response induced by the cell mediated immune response. In recent years, it is one of the hot spots in the field of organ transplantation. Previous studies have indicated that Tregs is not only found in the lymphoid tissues of transplanted organs, but also in the interior of the graft. Because the activation of Tregs is different, its immune suppression function is also different. If Tregs is used to prevent immune rejection, positioning and migration information is particularly critical. Chemokine receptors expression has been known to be important for lymphocyte homing to lymph nodes, and also contributes to chemokine-induced leukocyte migration within extravascular tissues. Preclinical studies clearly demonstrate that Tregs cells play an important role in transplantation tolerance induction, attracting most attention of investigators. [ABSTRACT FROM AUTHOR]