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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the correlation between serum immune inflammation related protein complexes（IIRPCs）,25-hydroxyvitamin D [25（OH）D], Chemerin（Chemerin） and disease activity and intestinal flora in patients with inflammatory bowel disease（IBD）. Methods: 150 patients with IBD who were treated in our hospital from December 2020 to December 2021 were selected,including 65 cases of ulcerative colitis（UC） group and 85 cases of Crohn’s disease（CD） group, and 70 healthy subjects in the same period were taken as the control group. The levels of serum IIRPCs, 25（OH）D and Chemerin in the three groups were detected and compared. In addition, patients in UC group and CD group were divided into active group and remission group according to the Crohn’s disease activity index（CDAI） and the modified Mayo score of ulcerative colitis. The levels of serum IIRPCs, 25（OH）D, Chemerin and intestinal flora between active group and remission group were compared, and correlation analysis was made. Results: The levels of serum IIRPCs and Chemerin in patients with IBD were higher than those in the control group, while the level of 25（OH）D was lower than that in the control group（P<0.05）. The levels of serum IIRPCs and Chemerin in UC group were higher than those in CD group, and the level of 25（OH）D was lower than that in CD group（P<0.05）. The levels of serum IIRPCs, Chemerin, Enterococcus, enterobacter, yeast and bacteroides in patients with active UC and CD were higher than those in patients with remission UC and CD, while the levels of serum 25（OH）D, bifidobacteria and lactobacillus were lower than those in patients with remission UC and CD（P<0.05）. Pearsonn correlation analysis showed that the levels of serum IIRPCs and Chemerin in patients with UC and CD were positively correlated with the number of Enterococcus, enterobacter, yeast and Bacteroides, and negatively correlated with the number of Bifidobacterium and Lactobacillus（P<0.05）. The level of serum 25（OH）D in patients with UC and CD was negatively correlated with the number of Enterococcus, enterobacter, yeast and Bacteroides, and positively correlated with the number of Bifidobacterium and Lactobacillus（P<0.05）. Conclusion: Serum IIRPCs, 25（OH）D and Chemerin are related to disease activity and intestinal flora in patients with IBD. The detection of the above indicators is of certain value in evaluating the severity of patients with IBD. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the expression profile long noncoding RNA (lncRNA) in oxidized low-density lipoprotein (ox-LDL) treated human umbilical vein endothelial cell (HUVEC) compared with normal HUVEC. Methods: The expression profiles of lncRNA and mRNA in ox-LDL treated HUVEC compared with normal HUVEC were analyzed through the human lncRNA microarray. Results: 141 lncRNAs and 113 mRNAs were identified to be different expression (fold change ≥2.0) in ox-LDL treated HUVEC compared with normal HUVEC. 35 lncRNAs and 28 mRNAs were identified to be different expression (fold change≥4.0). Conclusion: Compared with normal HUVEC, there are evidently differentially expressed profiles of lnc RNA in ox-LDL treated HUVEC. LncRNA may play a partial role in endothelial dysfunction and damage. [ABSTRACT FROM AUTHOR]