Search

Objective: To investigate the clinical efficacy of Mingmu Yanggan pill combined with pralofene eye drops in the treatment of perimenopausal dry eye. Methods: 103 cases with 206 eyes of perimenopausal dry eye patients in our hospital from July 2019 to August 2020 were selected. According to the random number table method, the patients were divided into the control group（treated with pranoprofen eye drops） and the experimental group（treated with Mingmu Yanggan pill on the basis of the control group） 51 cases with 102 eyes and 52 cases with 104 eyes respectively. The two groups were treated for 2 months. The efficacy, symptom score, tear inflammatory factors, quality of life, Schirmer I test（SIT）, tear film break-up time（BUT）, corneal fluorescein staining（FL） score and adverse reactions were compared between the two groups. Results: The total effective rate of the experimental group at 2 months after treatment was better than that of the control group（P<0.05）. 2 months after treatment, the dry eye, asthenopia, foreign body sensation, burning symptom score and FL score of the experimental group were lower than those of the control group（P<0.05）. 2 months after treatment,BUT and SIT of the experimental group were higher than those of the control group（P<0.05）. 2 months after treatment, the levels of interleukin-6（IL-6）, tumor necrosis factor-α（TNF-α） in tears of the experimental group were lower than those of the control group（P<0.05）. 2 months after treatment, the scores of mental health, eye pain, social activities and general health of the experimental group were higher than those of the control group（P<0.05）. There was no obvious discomfort in the two groups during treatment. Conclusion: Mingmu Yanggan pill combined with pranoprofen eye drops in the treatment of perimenopausal dry eye can improve the symptoms of patients and tear film stability, reduce the level of inflammatory factors in tears, improve the quality of life of patients, which is safe and effective. [ABSTRACT FROM AUTHOR]