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Objective: To explore the effect of acacetin on myocardial ischemia reperfusion injury in rats and its possible mechanism. 24 SPF rats were randomly divided into sham operation group, model control group, acacetin administration group, acacetin+AG490 group, with 6 rats in each group. Myocardial ischemia reperfusion injury model was induced by 30 minutes coronary occlusion followed by 2 h reperfusion in rats. The myocardial infarct area was measured by triphenyltetrazolium chloride, the activities of CK-MB and LDH in serum were detected by ultraviolet spectrophotometer and enzyme linked immunoassay, and the relative expression levels of Bcl-2, Bax, Stat3 and p-Stat3 proteins in myocardium were investigated by Western blot. Compared with the sham operation group, the activities of CK-MB and LDH in serum rose obviously in the model group (P<0.01), the percentage of myocardial infarction area increased significantly (P<0.01), the ratio of p-Stat3/Stat3 and Bcl-2/Bax decreased notably (P<0.01); Compared with the model group, the activities of CK-MB and LDH, the percentage of myocardial infarction area were significantly decreased (P<0.05), and the ratios of Bcl-2/Bax and p-Stat3/Stat3 were increased significantly in the acacetin treated group. However, the protective effect of acacetin on damaged myocardium was cleared by AG490 in the group of acacetin+AG490. Acacetin could alleviate myocardial damage and exert myocardial protection in MIRI rats, and its mechanism might be related to the inhibition of cardiomyocyte apoptosis by activating Jak2/Stat3 signal pathway. [ABSTRACT FROM AUTHOR]

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Objective: A new method of treatment of male urinary catheter after pulling out urinary dysfunction. Methods:Application of general surgery spinal anesthesia plus postoperative epidural catheter out after 60 cases of patients with voiding dysfunction were randomly divided into 2 groups, A group: 30 cases of the implementation of 2% lidocaine 5m L+ application of 10 m L normal saline 5m L urinary tract by syringe injection 5 minutes after the reservation; B group: 30 cases of conventional heat treatment of lower abdomen. Results: A group of patients with 2 to 5-hour urine, B group of 13 cases of 2 to 5 hours of urination, urinary retention is still 15 cases, the final Group A and after the application of all the urine. Conclusion: Transurethral given lidocaine injection in treatment of male urinary dysfunction after operation has good clinical effects, it is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)