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Objective: To investigate the relationship between Bilirubin blood lipid Comprehensive index and apolipoprotein B and the severity of coronary lesions of female patients with coronary artery disease(CAD). Methods: A total of 246 cases of female patients with coronary angiography were divided into 2 sets of groups.(1)According to the results of coronary angiography, the female patients were divided into the CAD group(n=141) and normal control group(n=105);(2)By Gensini scoring system, the female patients were divided into 4 quartile groups: 1 st quartile group(n=35), 2 nd quartile group(n=32), 3 rd quartile group(n=39) and 4 th quartile group(n=35). The blood level of total bilirubin(TBIL), direct bilirubin(DBIL), indirect bilirubin(IBIL), total cholesterol(TC), triglyceride(TG),low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), apolipoprotein A/B(ApoA/B) level were measured. Bilirubin blood lipid Comprehensive index [TC/(HDL-C+TBIL), LDL-C/(HDL-C+TBIL)] were calculated. Results:(1) The levels of TC, TG, LDL-C and ApoB in CAD group were higher than those of the normal control group; the HDL-C, ApoA, TBIL, DBIL and IBIL were lower than those of the normal control group(P0.05); Compared with the normal group, the ratios of TC/(HDL-C+TBIL)and LDL-C/(HDL-C+TBIL) were increased(P0.05).(2)By Gensini scoring system, the level of TC, LDL-C, ApoB, TBIL, DBIL, IBIL,ratios of TC/(HDL-C+TBIL) and LDL-C/(HDL-C+TBIL) were different among 4 groups(P<0.05).(3)Correlation analysis showed that TC/(HDL-C+TBIL), LDL-C/(HDL-C+TBIL) and ApoB were positively related to Gensini scoring system(r=0.538, P<0.05; r=0.670, P<0.05 and r=0.462, P<0.05). But TBIL, DBIL, IBIL were negatively related to Gensini scoring system(r=-0.485, P0.05; r=-0.564, P0.05 and r=-0.359, P0.05). Conclusions:(1)Bilirubin blood lipid Comprehensive index and apolipoprotein B were significantly higher than the control group, while TBIL, DBIL, IBIL decreased.(2)Bilirubin blood lipid Comprehensive index and apolipoprotein B were positively related to the severity of coronary artery lesions of female CAD patients. [ABSTRACT FROM AUTHOR]