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Objective: To explore the correlation between fractional exhaled nitric oxide（FeNO）, 1, 25-dihydroxyvitamin D3[1,25（OH）2D3], children asthma control test（C-ACT） scores and pulmonary function in children with asthma. Methods: 86 children with asthma in our hospital from June 2017 to June 2018 were selected as the observation group, and another 86 healthy children who were received physical examination in our hospital during the same period were selected as control group. The concentrations of 1, 25（OH）2D3,levels of FeNO, forced expiratory volume in one second（FEV1） and peak expiratory flow（PEF） were compared between the two groups.The concentrations of 1,25（OH）2D3, levels of FeNO, C-ACT, FEV1 and PEF in children with different stages of disease were compared.The correlation between 1,25（OH）2D3, FeNO, C-ACT and pulmonary function in children with asthma was analyzed. Results: The concentration of 1,25（OH）2D3 and the levels of PEF, FEV1 in observation group were significantly lower than those of the control group（P<0.05）, while the level of FeNO was significantly higher ower than that of the control group（P <0.05）. With the aggravation of the patient’s condition, the concentrations of 1,25（OH）2D3, levels of PEF, FEV1, C-ACT scores were decreased gradually, while the level of FeNO was increased gradually, and the differences were statistically significant between children in different status（P<0.05）. 1,25（OH）2D3 in children with asthma was positively correlated with FEV1, PEF（r=0.912, 0.873, P=0.006, 0.008）. C-ACT was positively correlated with FEV1, PEF（r=0.472, 0.366, P=0.036, 0.032）. FeNO was not correlated with FEV1, PEF（r=-0.035,-0.124, P=0.075, 0.064）.Conclusion: The concentrations of 1,25（OH）2D3 and C-ACT scores in children with asthma are significantly decreased, and the level of FeNO is increased significantly. 1, 25（OH）2D3 and C-ACT scores are positively correlated with lung function, but FeNO is not correlated with lung function. C-ACT can be used to predict the condition of children with asthma, at the same time, lung function of children with asthma can be improved by increasing the concentration of 1,25（OH）2D3. [ABSTRACT FROM AUTHOR]

Alternative splicing is a process that the pre-mRNA selected different splice sites to produce numerbous of similar or opposite mRNA splicing isoforms. As a splicing regulatory factor, Polypyrimidine tract binding protein can bind to mRNA to inhibit the occurrence of alternative splicing. The disorder of splicing regulation can lead to the occurrence of tumor and many kinds of diseases. In this paper, the research progress of the structure characteristics and the correlation between alternative splicing and clinical disease of alternative splicing regulatory protein PTB and its homologous protein is described in detail. According to the level of gene transcription regulation, there is a deeper understanding of the occurrence, development and prognosis of the disease, and has important application prospects in many diseases. [ABSTRACT FROM AUTHOR]

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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)