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Objective: To investigate the correlation between body mass index, endocrine and metabolic markers in patients with polycystic ovary syndrome. Methods: 53 patients who suffered polycystic ovary syndrome from October 2016 to July 2017 were grouped according to BMI, HOMA-IR and testosterone levels. Body weight index(BMI), blood biochemistry, insulin, C peptide and sex hormone and endocrine and metabolic indicators were tested and analyzed. Results: Grouped according to the level of BMI, there were statistical significance in fasting insulin, 60 minutes insulin, 120 minutes of insulin, fasting C peptide, 60 minutes C peptide, 120 minutes C peptide,total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein(P<0.05); Grouped according to the level of the HOMA-IR index, there were statistical significance in fasting blood glucose, 60 minutes blood glucose, 120 minutes blood glucose, fasting insulin,60 minutes insulin, 120 minutes insulin, fasting C peptide, 60 minutes C peptide, 120 minutes C peptide, total cholesterol, triglyceride,low density lipoprotein, high density lipoprotein, LH/FSH, testosterone and estradiol(P<0.05); grouped according to testosterone, there were statistical significance in BMI, fasting insulin, 60 minutes insulin, 120 minutes of insulin, HOMA index, luteinizing hormone, LH/FSH, testosterone and estradiol(P<0.05). Conclusion: Polycystic ovary syndrome(PCOS) is complicated and changeable. It should be treated differently according to the body mass index, endocrine and metabolic characteristics, so as to improve the cure level and quality of life. [ABSTRACT FROM AUTHOR]

miRNAs are endogenous non-coding RNAs about 22 nucleotides in length that play an important role in posttranscriptional regulation, also play an important role in physiological and pathological.So far, there have been found 24521 miRNA molecules in animals and plants as well as the virus, miR-378 is one of the family of miRNAs.miR-378 is closely related to the occurrence and development of many diseases through a variety of mechanisms.In different tissues, miR-378 plays different roles.miR-378 plays the role of tumor suppressor genes in gastric cancer, liver cancer and colorectal cancer.miR-378 has the opposite effect on ovarian cancer, pancreatic cancer and leukemia.In the field of cardiovascular diseases, miR-378 can protect blood vessel, delay cardiovascular disease development by a variety of mechanisms.In bone metabolism, miR-378 can inhibit or promote osteoblast differentiation through different mechanisms.This paper will introduce the relationships between miR-378 and tumors, cardiovascular, bone metabolism and other aspects, in order to provide a new idea for the treatment and prevention of these diseases. [ABSTRACT FROM AUTHOR]