Search

Objective: To study the effect of lipoprotein lipase (LPL) gene knockout on lung injury in mice with cerulein-induced hyperlipidemia and acute pancreatitis. Methods: C57BL/6 mice were divided into three groups. The Control group and the AP-Model group were wild-type C57 BL/6 mice, and the LPL ko group was the LPL knockout C57 BL/6 mice; the Control group was fed normally, and the AP-Model and A hyperlipidemia acute pancreatitis model was established in the LPL ko group of mice, and the mortality, pancreatic and lung pathological damage, and serum amylase (AMY), malondialdehyde (MDA), tumor necrosis and tumor necrosis levels were compared among the three groups. Factor-α(Tumor necrosis factor-α, TNF-α) and interleukin-6 (Interleukin-6, IL-6) content. Results: 48 hours after the establishment of acute pancreatitis, the mortality rates of mice in the Control group, AP-Model group and LPL ko group were 0%, 20% and 40%, respectively. Compared with the control group, the pancreas and lung tissue wet/dry weight ratios, pancreas and lung histopathological scores, serum AMY, MDA, TNF-αand The content of IL-6 was significantly increased (P<0.05); compared with the AP-Model group, the pancreas and lung tissue wet/dry weight ratio, pancreas and lung tissue pathology of LPL ko group mice 24 and 48 hours after the induction of acute pancreatitis Scores, serum AMY, MDA, TNF-αand IL-6 levels were significantly increased (P<0. 05). Conclusion: LPL knockout mice had more severe acute hyperlipidemic pancreatitis lung injury, and the mechanism may be related to the stronger oxidative stress and inflammation induced by LPL knockout. [ABSTRACT FROM AUTHOR]

Objective: To explore the efficacy and safety of self expanding stent assisted coil embolization in the treatment of intracranial aneurysms. Methods: From January 2014 to January 2019,159 patients with intracranial aneurysms were treated with self expanding stent assisted coil embolization (group A) and 178 patients with intracranial aneurysms (group B) were treated with simple coil embolization. The operative time, postoperative hospital stay, follow-up time and complications of the two methods were compared, and the safety and efficacy of the two methods were compared by Glasgow(GOS) prognosis score and Raymond score. Results: There was no significant difference in operation time, postoperative hospitalization time and follow-up time between the two groups (P>0.05). There was significant difference in the incidence of postoperative bleeding and ischemic events between the two groups (P<0.05), but there was no significant difference in the incidence of hydrocephalus, pneumonia, mortality and disability between the two groups(P=1 after continuous correction). The GOS score of group A was higher than that of group B within 1 month and 12 months after operation, the difference was statistically significant (P<0.05); the Raymond grade of group A was better than that of group B within 1 month and 12 months after operation, the difference was statistically significant (P<0.05). Conclusion: Self expanding stent assisted coil embolization is effective for intracranial aneurysm embolization and has few postoperative complications. For patients with intracranial aneurysms, self expanding stent assisted coil embolization can improve the safety of operation and the efficacy of embolization. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)