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Objective: The clinical characteristics of patients with different types of hypertrophic cardiomyopathy (HCM) and the correlation between serum soluble oncogenic inhibitor 2 (s ST2), γ-glutamyl transferase (GGT) expression and cardiac function were analyzed. Methods: A total of 96 patients with HCM admitted to our hospital from January 2020 to January 2023 were selected as the study objects. The HCM patients were divided into OHCM group (44 cases) and NOHCM group (52 cases) according to the measurement results of LVOTG between left ventricular outflow tract and aorta in exercise load test. The heart function of the two groups was graded according to the New York Heart Association (NYHA) . The clinical characteristics of the two groups of patients were investigated by using a self-made questionnaire, and serum s ST2 and GGT levels were detected by enzyme-linked immunosorbent assay. Serum s ST2,GGT and cardiac function indexes [left ventricular end-diastolic left atrial volume (LAV), left ventricular ejection fraction (LVEF), left ventricular end-diastolic inner diameter (LVD), left atrial volume index (LAVI), E/E ’, E/A, N-terminal B-type brain natriuretic peptide (NT-pro BN) were analyzed by bivariate Spearman correlation test P), 6min walking distance (6MWD) ]; In addition, multivariate Logistic model was established to analyze the effects of serum s ST2 and GGT on cardiac function in patients with OHCM and NOHCM, and the predictive value of serum s ST2 and GGT on different cardiac function in patients with OHCM and NOHCM. Results: Compared with NYHA I + II, the levels of s ST2, GGT, LVD, LAV, LAVI, E/E ’, NT-porBNP in OHCM and NOHCM groups with NYHA ≥ III were higher, the levels of LVEF and E/A were lower, and the 6MWD was shorter (P＜0.05) . OHCM group and NOHCM group were negatively correlated with LVEF, E/A and 6MWD, and positively correlated with LVD, LAV, LAVI, E/E ’ and NT-porBNP (P＜0.05) .Multivariate Logistic results showed that serum s ST2 and GGT were independent risk factors affecting cardiac function in patients with OHCM and NOHCM (P＜0.05) . The ACU of serum s ST2 and GGT in the prediction of NYHA ≥ III in OHCM and NOHCM patients was ＞ 0.75. Conclusion: Serum s ST2 and GGT are related to the cardiac function of different types of HCM, and the degree of cardiac function damage can be effectively evaluated according to the changes of their expression levels. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between serum lipoprotein(a) [Lp(a)], uric acid (UA) and γ-glutamyl transferase (GGT) with coronary artery lesions and major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods: 100 patients with acute STEMI undergoing PCI admitted to the Department of Internal Medicine-Cardiovascular of the Second Affiliated Hospital of Anhui Medical University from January 2019 to July 2022 were selected as the acute STEMI group. 56 patients were divided into the non-severe lesion group and 44 patients in the severe lesion group according to the Gensini score. The patients were followed up for 3 months after PCI and were divided into MACE subgroup and non-MACE subgroup according to whether MACE occurred. 50 patients with coronary angiography excluding coronary artery disease in the same period were also selected as the control group. Clinical data of patients with acute STEMI were collected, and serum Lp(a), UA, and GGT levels were detected. The correlation between serum Lp(a), UA, GGT levels and Gensini score in patients with acute STEMI and the influencing factors of MACE after PCI were analyzed. Results: Compared with control group, serum Lp(a), UA and GGT levels in the STEMI group were increased (P＜0.05). The Lp(a), UA and GGT levels in the severe lesion group were higher than those in the non-severe lesion group (P＜0.05). Spearman correlation coefficient analysis showed that serum Lp(a), UA, GGT levels were positively correlated with Gensini score in patients with acute STEMI (P＜0.05). 3 months after follow-up, the incidence of MACE in 100 patients with acute STEMI after PCI was 21.00%(21/100). Multivariate Logistic regression analysis showed that the increased age, KILLIP cardiac function grade≥Ⅲ, elevated Lp (a), UA and GGT were independent risk factors for MACE after PCI, and the elevated left ventricular ejection fraction (LVEF) was independent protective factor (P＜0.05). Conclusion: Elevated serum Lp(a), UA and GGT levels in patients with acute STEMI are closely correlated with the severity of coronary artery lesions and MACE after PCI, and may be the auxiliary predictors of MACE after PCI in acute STEMI patients. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation of serum γ-glutamyl transferase(GGT) level with the influencing factors of coronary heart disease and the severity of patients with vascular disease. Methods: 61 patients diagnosed as coronary heart disease(CHD)from July 2013 to October 2017 in our hospital through coronary angiography were selected as the experimental group, which were divided into stable angina pectoris group(hereinafter referred to as A group, 20 cases), unstable angina(group B, 21 cases) and acute myocardial infarction(group C, 20 cases) according to their clinical symptoms. In the same period, thirty patients without coronary heart disease were selected as the control group. The levels of fasting blood glucose(FBG), total cholesterol(TC), triglyceride(TG), systolic blood pressure(SBP), diastolic blood pressure(DBP) and uric acid in the four groups were measured and compared. The correlation of coronary Gensini score. Finally, the GGT and Gensini scores of four groups of patients were analyzed. Results:(1) The FBG, serum TC,TG, SBP, DBP and uric acid levels in the four groups were significantly different(Group C>Group B>Group A>Control group, P<0.05);(2)The level of GGT was positively correlated with the above risk factors(r=0.236, 0.351, 0.316, 0.239, 0.301, 0.395, P=0.035, 0.000,0.000, 0.0034, 0.001, 0.000);(3)Both GGT and Gensini scores in the four groups were changed according to the trend of Group C>Group B>Group A>Control group(P<0.05);(4) The serum GGT level of patients with coronary heart disease was positively correlated with Gensini score(r=0.681, P=0.000). Conclusion: The serum GGT levels of CHD patients were positively correlated with the serum levels of FBG, TC, TG, SBP, DBP, uric acid levels and the severity of the vascular lesions, it may be used to predict the severity of lesion in CHD patients. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical value of colour ultrasonic combined with glutamyl transpeptidase (GGT) detection in the diagnosis of alcoholic fatty liver of patients with alcohol dependence. Methods: A total of 39 patients with alcohol dependence, who were admitted to Guangzhou Huiai Hospital from May 2013 to April 2014, were chosen as study group; the other 40 healthy people from the hospital staff and training medical personnel, as control group. The two groups were detected with liver colour ultrasonic and GGT test, and the detection results were analyzed. Results: The serum GGT level (189.95± 226.52 U/L) in the study group was significantly higher than that (26.85± 18.94 U/L) in the control group, the difference was statistically significant (t=4.54, P<0.001); There were significant differences in the level of GGT between the patients with alcoholic fatty liver and the patients with non alcoholic fatty liver in the study group (P<0.05), which was significantly higher than the patients with alcoholic fatty liver in the control group the difference was statistically significant (P<0.05). Conclusion: Colour ultrasonic combined with GGT detection can enhance the clinical detection rate of alcoholic fatty liver. Serum GGT is a high sensitivity detection index for the patients with alcohol dependence, and the GGT detection is helpful for the discovery of early alcoholic disease. [ABSTRACT FROM AUTHOR]