1. 黑龙江地区400 例乙型肝炎病毒基因分型与耐药突变研究.
- Author
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张怡, 陈思, 谢晓丹, 张蕾, and 张倩
- Abstract
Objective: To investigate the distribution characteristics of hepatitis B virus (HBV) genotypes and the variation situation of drug resistance gene in Heilongjiang area by the gene chip technology.Methods:Serum samples were randomly collected from 400 patients of hepatitis B in our hospital from November 2012 to November 2015.The HBV genotypes and drug resistance associated multiple sites in common 4 types of antiviral drug were detected by the gene chip technology of PCR combined with reverse dot blot.Results:Among 400 samples in Heilongjiang area,83.25 % genotypes were genotype C (333 cases),type B 7.25 % (29 cases),type D 0.25 % (1 case) and mixed type 2.75 % (11 cases);188 sites were found to be resistance mutants,the total resistance frequency was 45.19 %,rt236T mutations in 10 samples prompted drug resistance-mutations for Adefovir drug,and the resistance frequency was 5.82 %,and 126 samples drugs resistance-mutations was Lamivudine drug in major ofrt204I and (rt180M+rt204V).126 cases were related with Lamivudine resistance,which was significantly higher than other antiviral drugs,the risk of drug resistance was greater.Conclusions:The main HBV genotype is the genotype C in Heilongjiang area,genotype B and mixed genotype are unusual,which is more likely to happen resistance to Lamivudine. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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