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Head and Neck Cancer (HNC), including tumors in oral cavity, pharyngeal, nasal cavity and laryngeals, which has a high prevalence and complex pathogenesis. Whereas, laryngocarcinoma is the world's sixth common form of malignant tumors and accounts for over 3% of malignant HNCs. Therefore, laryngocarcinoma should be given particular attention in HNCs. Human papillomavirus (HPV) belongs to small double strands DNA virus. Previous studies have reported that HPV infection is associated with the occurrence and the prognosis of different tumors. Recently, the role of HPV infection to the carcinogenesis and clinical significance of HNC, especially to tumors in pharynx oralix has attracted a variety of scholars' concern. However, the role of HPV infection to laryngocarcinoma has not been defined. We reviewed the correlation of HPV infection and laryngocarcinoma, and the potential carcinogen effects of HPV infection. Although there were differences in the relevance ratio of HPV infection in laryngocarcinoma in different research teams, preliminary studies have indicated that the infection of high risk HPV subtypes, such HPV 16 and HPV 18, exist a certin correlation of the occurrence rate of laryngocarcinoma. DNA of HPV virus integrates with the tumor cells, and the expression of p16 was higher in laryngocarcinoma cells. But the prevention and accurate treatment of diseases caused by HPV infection remains unclear, further research is required to clarify the mechanism underlying HPV infection involvement in HNC. [ABSTRACT FROM AUTHOR]

Objective: To research the efficacy of partial laryngectomy combined with sinupret drugs on patients with laryngocarcinoma. Methods: 102 cases of patients with laryngocarcinoma who were treated with PL surgery in our hospital from March2008 to March 2013 were chosen and randomly divided into observation group(51 cases) and control group(51 cases). The control group received antibiotics and nasal feeding, inhalation therapy and other programs, while the observation group was treated with sinupret drugs besides treatment of the control group. The clinical efficacy and postoperative pulmonary infection after 10 days of treatment were compared, and after six months of follow-up, the acoustic parameters were compared. Results: The effect of the observation group was significantly higher than that of control group, and the difference was statistically significant(P<0.05). The difference in Jitter, shimmer and normalized noise value(NNE) between observation group and control group were not statistically significant(P> 0.05). There were 5 cases of pulmonary infection in the observation group, which accounted for 9.80%, and was significantly lower than that in the control group(15 cases, accounting for 29.41%)(P<0.05). Conclusion: PL operation combined with Sinupret is effective in treatment of laryngeal cancer patients, can reduce pulmonary infection, and is worthy of recommendation. [ABSTRACT FROM AUTHOR]