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Start Over Descriptor "brain pH" Journal progress in neurobiology
2 results on '"brain pH"'

1. The brain acid–base homeostasis and serotonin: A perspective on the use of carbon dioxide as human and rodent experimental model of panic.

Author

Leibold, N.K., van den Hove, D.L.A., Esquivel, G., De Cort, K., Goossens, L., Strackx, E., Buchanan, G.F., Steinbusch, H.W.M., Lesch, K.P., and Schruers, K.R.J.

Subjects
*BRAIN physiology, *SEROTONIN, *HOMEOSTASIS, *CARBON dioxide, *LABORATORY rodents
Abstract

Panic attacks (PAs), the core feature of panic disorder, represent a common phenomenon in the general adult population and are associated with a considerable decrease in quality of life and high health care costs. To date, the underlying pathophysiology of PAs is not well understood. A unique feature of PAs is that they represent a rare example of a psychopathological phenomenon that can be reliably modeled in the laboratory in panic disorder patients and healthy volunteers. The most effective techniques to experimentally trigger PAs are those that acutely disturb the acid–base homeostasis in the brain: inhalation of carbon dioxide (CO 2 ), hyperventilation, and lactate infusion. This review particularly focuses on the use of CO 2 inhalation in humans and rodents as an experimental model of panic. Besides highlighting the different methodological approaches, the cardio-respiratory and the endocrine responses to CO 2 inhalation are summarized. In addition, the relationships between CO 2 level, changes in brain pH, the serotonergic system, and adaptive physiological and behavioral responses to CO 2 exposure are presented. We aim to present an integrated psychological and neurobiological perspective. Remaining gaps in the literature and future perspectives are discussed. [ABSTRACT FROM AUTHOR]

Published
2015
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2. The brain acid-base homeostasis and serotonin: A perspective on the use of carbon dioxide as human and rodent experimental model of panic

Author

Gordon F. Buchanan, K. De Cort, Gabriel Esquivel, Koen Schruers, Harry W.M. Steinbusch, Nicole Leibold, Klaus-Peter Lesch, D.L.A. van den Hove, E. Strackx, Liesbet Goossens, Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, and Kindergeneeskunde

Subjects
Serotonin, Serotonergic, Hyperventilation, medicine, Animals, Homeostasis, Humans, Panic disorder, Inhalation, General Neuroscience, Perspective (graphical), Panic, Brain, Carbon Dioxide, Hydrogen-Ion Concentration, medicine.disease, Brain pH, Animal models, Human models, CO2, medicine.symptom, Psychology, Neuroscience, Psychopathology
Abstract

Panic attacks (PAs), the core feature of panic disorder, represent a common phenomenon in the general adult population and are associated with a considerable decrease in quality of life and high health care costs. To date, the underlying pathophysiology of PAs is not well understood. A unique feature of PAs is that they represent a rare example of a psychopathological phenomenon that can be reliably modeled in the laboratory in panic disorder patients and healthy volunteers. The most effective techniques to experimentally trigger PAs are those that acutely disturb the acid-base homeostasis in the brain: inhalation of carbon dioxide (CO2), hyperventilation, and lactate infusion. This review particularly focuses on the use of CO2 inhalation in humans and rodents as an experimental model of panic. Besides highlighting the different methodological approaches, the cardio-respiratory and the endocrine responses to CO2 inhalation are summarized. In addition, the relationships between CO2 level, changes in brain pH, the serotonergic system, and adaptive physiological and behavioral responses to CO2 exposure are presented. We aim to present an integrated psychological and neurobiological perspective. Remaining gaps in the literature and future perspectives are discussed.

Published
2015

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