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Your search keyword '"Cumhuriyet Universitesi"' showing total 2 results
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2 results on '"Cumhuriyet Universitesi"'

1. Dimerization and ion binding properties of S100P protein.

Author

Tutar Y

Subjects
Calcium metabolism, Calcium-Binding Proteins genetics, Circular Dichroism, Dimerization, EF Hand Motifs, Humans, Hydrophobic and Hydrophilic Interactions, Kinetics, Magnesium metabolism, Mutation, Neoplasm Proteins genetics, Protein Conformation, Protein Structure, Secondary, Recombinant Proteins chemistry, Recombinant Proteins metabolism, Spectrometry, Fluorescence, Spectrophotometry, Ultraviolet, Calcium-Binding Proteins chemistry, Calcium-Binding Proteins metabolism, Neoplasm Proteins chemistry, Neoplasm Proteins metabolism
Abstract

Functional S100P requires dimer formation and dimerization might form for one of the two reasons: i. producing a pair of sites for target protein binding or ii. modulation of cation binding affinity. The extent of exposed protein hydrophobicity was related to dimer formation.

Published
2006
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2. Target peptide recognition by S100P protein and role of central linker region and dimer interface.

Author

Tutar Y

Subjects
Calcium metabolism, Calorimetry, Chromatography, Gel, Dimerization, Hydrophobic and Hydrophilic Interactions, Kinetics, Melitten chemistry, Melitten metabolism, Peptides chemistry, Peptides metabolism, Protein Conformation, Protein Structure, Secondary, S100 Proteins chemistry, S100 Proteins genetics, Spectrometry, Fluorescence, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Tryptophan chemistry, Tyrosine chemistry, S100 Proteins metabolism
Abstract

Interaction between S100P and its target protein is an essential step in several cellular functions. The amphipathic mellitin peptide binds tightly to S100P protein in the presence of calcium cation. Since little is known about the recognition sequence, mellitin interaction form a model for S100P. Interaction between mellitin and protein examined to identify key regions required for the protein-protein interaction.

Published
2006
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