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10 results on '"Camoin, Luc"'

2. Glial-cell-mediated re-induction of the blood-brain barrier phenotype in brain capillary endothelial cells: A differential gel electrophoresis study

Author

Deracinois, Barbara, primary, Pottiez, Gwënaël, additional, Chafey, Philippe, additional, Teerlink, Tom, additional, Camoin, Luc, additional, Davids, Mariska, additional, Broussard, Cédric, additional, Couraud, Pierre-Olivier, additional, Dehouck, Marie-Pierre, additional, Cecchelli, Roméo, additional, Karamanos, Yannis, additional, and Flahaut, Christophe, additional

Published
2013
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3. Proteomes of umbilical vein and microvascular endothelial cells reflect distinct biological properties and influence immune recognition

Author

Dib, Hanadi, primary, Chafey, Philippe, additional, Clary, Guilhem, additional, Federici, Christian, additional, Le Gall, Morgane, additional, Dwyer, Julie, additional, Gavard, Julie, additional, Tamas, Nicolas, additional, Bussone, Guillaume, additional, Broussard, Cédric, additional, Camoin, Luc, additional, Witko-Sarsat, Véronique, additional, Tamby, Mathieu C., additional, and Mouthon, Luc, additional

Published
2012
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4. Proteomic analysis of oligodendrogliomas expressing a mutant isocitrate dehydrogenase‐1

Author

Thirant, Cécile, primary, Varlet, Pascale, additional, Lipecka, Joanna, additional, Le Gall, Morgane, additional, Broussard, Cédric, additional, Chafey, Philippe, additional, Studler, Jeanne‐Marie, additional, Lacombe, Joelle, additional, Lions, Séverin, additional, Guillaudeau, Angélique, additional, Camoin, Luc, additional, Daumas‐Duport, Catherine, additional, Junier, Marie‐Pierre, additional, and Chneiweiss, Hervé, additional

Published
2011
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6. Proteomic analysis of β-catenin activation in mouse liver by DIGE analysis identifies glucose metabolism as a new target of the Wnt pathway

Author

Chafey, Philippe, primary, Finzi, Laetitia, additional, Boisgard, Raphael, additional, Caüzac, Michèle, additional, Clary, Guillem, additional, Broussard, Cédric, additional, Pégorier, Jean-Paul, additional, Guillonneau, François, additional, Mayeux, Patrick, additional, Camoin, Luc, additional, Tavitian, Bertrand, additional, Colnot, Sabine, additional, and Perret, Christine, additional

Published
2009
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10. Proteomic analysis of beta-catenin activation in mouse liver by DIGE analysis identifies glucose metabolism as a new target of the Wnt pathway.

Author

Chafey P, Finzi L, Boisgard R, Caüzac M, Clary G, Broussard C, Pégorier JP, Guillonneau F, Mayeux P, Camoin L, Tavitian B, Colnot S, and Perret C

Subjects
Animals, Electrophoresis, Gel, Two-Dimensional, Gene Deletion, Gene Expression Regulation, Male, Mass Spectrometry, Mice, Proteome genetics, Proteome metabolism, Signal Transduction, Genes, APC, Glucose metabolism, Liver metabolism, Proteome analysis, Wnt Proteins metabolism, beta Catenin metabolism
Abstract

The Wnt/beta-catenin signaling pathway has been increasingly implicated in liver development and physiology. Aberrant activation of this pathway is one of the major genetic events observed during the process of human HCC development. To gain insight into the mechanism underlying beta-catenin action in the liver, we conducted a quantitative differential proteomic analysis using 2-D DIGE combined with MS, in mice with liver-specific deletion of Apc resulting in acute activation of beta-catenin signaling (Apc(KOliv) mice). We identified 94 protein spots showing differential expression between mutant Apc(KOliv) and control mice, corresponding to 56 individual proteins. Most of the proteins identified were associated with metabolic pathways, such as ammonia and glucose metabolism. Our analysis showed an increase in lactate dehydrogenase activity together with a downregulation of two mitochondrial ATPase subunits (ATP5a1 and ATP5b). These observations indicate that beta-catenin signaling may induce a shift in the glucose metabolism from oxidative phosphorylation to glycolysis, known as the "Warburg effect". Imaging with (18)F-fluoro-2-deoxy-D-glucose-positron emission tomography suggests that the specific metabolic reprogramming induced by beta-catenin in the liver does not imply the first step of glycolysis. This observation may explain why some HCCs are difficult to assess by fluoro-2-deoxy-D-glucose-positron emission tomography imaging.

Published
2009
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