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Discusses a study conducted by researchers from China, which concludes that several genes are involved in the onset of senility. Authors of the study; Implications of the findings for geriatrics research; Periodical where the study was published.

Discusses a study conducted by researchers from China, which suggests that removal of disulfide A7-B7 will result in serious loss of biological activity and the native conformation of insulin, even if the disulfide is replaced by residues with a negative charge. Authors of the study; Implications of the findings for insulin research; Periodical where the study was published.

The article cites a study which finds that Zwint-1 plays a key role in mitotic checkpoint signaling in human cells. Researcher H.M. Wang and coauthors said that chromosome segregation in mitosis is orchestrated by dynamic interaction between spindle microtubules and the kinetochore, a multiprotein complex assembled onto centromeric DNA of the chromosome. Zwint-1 is required and is sufficient for kinetochore localization of Zeste White 10 (ZW10) in HeLa cells. Wang and colleagues published the results of their study in the "Journal of Biological Chemistry."

This article cites a study conducted by W.F. Tan and colleagues, published in the 2004 issue of the "European Journal of Pharmacology," which states that Pseudolarix acid B opposes the anti-apoptotic effects of vascular endothelial growth factor (VEGF). According to the study from the Peoples Republic of China, angiogenesis is controlled by a number of growth factors, including VEGF. In this study, pseudolarix acid 13, isolated from the traditional Chinese medicinal plant Pseudolarix kaempferi and originally identified as an early pregnancy-terminating agent, was evaluated for its potential as an angiogenesis inhibitor, using in vitro and in vivo models.

The article reports that a copolymer microsphere system has been developed for the chiral separation of amino acids. A new packing material for ligand-exchange chromatography, L-proline-modified hydrolyzed vinyl acetate-divinylbenzene copolymer microspheres, was prepared and evaluated in a recent study from China, conducted by researcher Z.K. Chai and coauthors. The support, which has an L-proline content of 0.35 mmol/g (nitrogen analysis), provides good enantioselectivity and column efficiency. Chai and colleagues published their study in the journal "Chromatographia."

This article reports that neuronal tau acts as chaperone protein for lactate dehydrogenase and functionally similar enzymes. R. Tian and coauthors at the Chinese Academy of Sciences in Beijing note that in a recent study from China, inactivation of lactate dehydrogenase in the presence of human microtubule-associated tau. Furthermore, the reactivation yield of LDH decreases significantly with delayed addition of tau. These findings suggest that "neuronal tau non-specifically functions as a chaperonelike protein towards the enzymes of carbohydrate metabolism. Tian and colleagues published their study in "Neurochemical Research."

According to a study, Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-infused rats and human embryonic kidney 293 Swedish mutant cells. Researcher Hai Yan Zhang and colleagues concluded that in the human embryonic kidney 293 cells, the level of amyloid precursor proteins was increased significantly with HupA treatment and there was a similar change in protein kinase C-alpha level under the same condition. Zhang and associates published their study in the periodical "Neuroscience Letters."

According to a study conducted by researcher Wei-Xi Tian and colleagues, published in the 2004 issue of the journal "Life Sciences,"weight reduction by Chinese medicinal herbs may be related to inhibition of fatty acid synthase. Fatty acid synthase is reported as a potential new therapeutic target for the treatment of obesity. Thirty-one Chinese medicinal herbs used in weight reducing prescriptions of Traditional Chinese Medicine were investigated for FAS inhibition.

Discusses research being done on interactions between ibuprofen and lipoproteins in human blood plasma by using (1)H nuclear magnetic resonance spectroscopy, with reference to a study conducted by Yunhuang Yang and colleagues, published in the 2004 issue of the journal "Analytical Biochemistry." Groups of phospholipids; Interaction of ibuprofen with groups of phospholipids.

Discusses research being done on Alzheimer's disease with reference to a study by Peng Zhang et al, published in a 2003 issue of "Neuroscience Letters."

Discusses a study being done on the crystallography of Escherichia coli CcmG/DsbE protein, conducted by N. Ouyang and collaborators, published in the 2003 issue of the periodical "Acta Crystallographica Section D-Biological Crystallography."

Discusses research being done by Ming-Hua Li et al on the role of BmKK4, a scorpion venom toxin, in the inhibition of potassium currents in rat hippocampal neurons in vitro published in the 2003 issue of "Toxicon."

Discusses research being done on the effect of activated transcription factor c-Jun on multidrug resistance gene-1 expression.

Discusses research being done on immunoglobulin G purification with reference to a study by Y. Liu et al, published in a September 2003 issue of the "Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences."

Discusses research done on an epitope of severe acute respiratory syndrome-coronavirus nucleocapsid protein.

This article cites a study conducted by Jun Yang and collaborators, published in the journal "Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences," which states that a metabonomics method based on serum fatty acid profiles can discriminate type 2 diabetic patients from healthy controls. Metabonomics, the study of metabolites and their roles in various disease states, is a novel methodology arising from the post-genomics era. This methodology has been applied in many fields, including work in cardiovascular research and drug toxicology. In this study, metabonomics method was employed to the diagnosis of type 2 diabetes mellitus based on serum lipid metabolites.

The article reports that enzyme immobilization on modified PMMA microspheres has been characterized. In a recent study from China, [m]icro-sized acrolein-modified PMMA (poly[methyl methacrylate]) microspheres were used as the support for enzyme immobilization. The properties of immobilized enzyme as well as the immobilizing behavior were evaluated by S.J. Li and coauthors at the Chinese Academy of Sciences. The immobilized amount reached 76.8 mg/g support, which is relatively high compared with some analogous supports, according to the report. The K value was larger and the V was smaller in the immobilized from than in the free form.

The article cites a study conducted by researchers according to which incubation temperatures facilitate DNA hairpin structure reopening published in the "European Journal of Biochemistry." According to a study from the Peoples Republic of China, a novel method, based upon primer extension, has been developed for measuring the reopening temperature of a single type of DNA hairpin structure. This resulted in the appearance of double-stranded DNA that was detected on an agarose gel. This temperature is defined here as the hairpin reopening temperature.