1. Time-dependent exacerbation of amphetamine-induced taste aversions following exposure to footshock
- Author
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M.A. Gingras, W.J. Bowers, and Zalman Amit
- Subjects
Central Nervous System ,Male ,Taste ,Time Factors ,algemeen [Geneeskunde] ,Farmacotherapie van psychomotorische ziektebeelden ,fundamenteel en toegepast onderzoek ,Pharmacology ,chemistry.chemical_compound ,0302 clinical medicine ,Saccharin ,Central Nervous System Diseases ,Psychology ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,Niet-toepassingsgericht onderzoek ,Electroshock ,musculoskeletal, neural, and ocular physiology ,05 social sciences ,Psychology, Medical ,Geneeskunde: algemeen ,Life sciences ,Anesthesia ,Medicine ,Biologie ,psychological phenomena and processes ,medicine.drug ,Logic ,Pharmacology toxicology ,Drinking ,Medical sciences ,03 medical and health sciences ,Medical ,medicine ,Animals ,0501 psychology and cognitive sciences ,cardiovascular diseases ,050102 behavioral science & comparative psychology ,Bescherming en bevordering van de menselijke gezondheid ,Amphetamine ,Behavior ,Analysis of Variance ,Animal ,Neurosciences ,Classical conditioning ,Extinction (psychology) ,Pharmacotherapy of psychomotor diseases ,fundamental and applied research ,Rats ,Disease Models, Animal ,chemistry ,Disease Models ,Taste aversion ,030217 neurology & neurosurgery - Abstract
Previous studies have shown that stressors attenuate LiCl-induced conditioned taste aversions (CTA) but not morphine-induced CTA. The current studies examined the effects of footshock on the acquisition and extinction of amphetamine-induced CTA. Experiment 1 demonstrated that exposure to 30 footshocks between saccharin consumption and amphetamine injections did not alter either the acquisition or the extinction of amphetamine-CTA. Experiment 2 demonstrated that exposure to the same shock parameters 2 and 4 days before saccharin-amphetamine pairing increased the magnitude of amphetamine-CTA after one saccharin-amphetamine pairing and delayed the recovery from the CTA. Experiment 2 also demonstrated that footshock increased the initial neophobic response to novel saccharin but did not alter subsequent saccharin consumption among saline-injected animals. These results indicate that stress-induced facilitation of amphetamine CTA are time-dependent and contrast with reports that stressors attenuate LiCl CTA. They also add support to the contention that CTAs induced by self-administered drugs like amphetamine are qualitatively different from CTAs induced by toxic substances like LiCL.
- Published
- 1996