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2. Concentrations of thioridazine and thioridazine metabolites in erythrocytes

Author

Mårtensson E, Axelsson R, Nyberg G, and C. Svensson

Subjects
Adult, Male, Erythrocytes, Metabolite, Thioridazine, Sulfone, chemistry.chemical_compound, Pharmacokinetics, Blood plasma, medicine, Humans, Biotransformation, Aged, Pharmacology, Chromatography, Chemistry, Sulfoxide, Middle Aged, Red blood cell, medicine.anatomical_structure, Biochemistry, Plasma concentration, Female, Oxidation-Reduction, medicine.drug
Abstract

The concentrations of thioridazine and its main metabolites in erythrocytes from 61 thioridazine-treated patients were determined by gas-liquid chromatography. The mean and range of the erythrocyte concentrations, expressed as percentage of the corresponding plasma concentrations, were: thioridazine, 5.1% (2.0–10.6); side-chain sulfoxide, 5.6% (1.6–10.4); side-chain sulfone, 3.3% (1.1–6.8); ring sulfoxide 2.7% (0.8–4.9). The erythrocyte and plasma concentrations were significantly correlated. The erythrocyte/plasma concentration ratios, all the erythrocyte concentrations, but none of the plasma concentrations except ring sulfoxide were significantly positively correlated to the dose of thioridazine. The erythrocyte/plasma concentration ratio was not correlated to age. In vitro experiments indicated no clinically relevant erythrocyte-mediated oxidation of thioridazine.

Published
1986

3. Concentrations of thioridazine and thioridazine metabolites in erythrocytes.

Author

Svensson C, Nyberg G, Axelsson R, and Mårtensson E

Subjects
Adult, Aged, Biotransformation, Female, Humans, Male, Middle Aged, Oxidation-Reduction, Thioridazine analogs & derivatives, Erythrocytes analysis, Thioridazine blood
Abstract

The concentrations of thioridazine and its main metabolites in erythrocytes from 61 thioridazine-treated patients were determined by gas-liquid chromatography. The mean and range of the erythrocyte concentrations, expressed as percentage of the corresponding plasma concentrations, were: thioridazine, 5.1% (2.0-10.6); side-chain sulfoxide, 5.6% (1.6-10.4); side-chain sulfone, 3.3% (1.1-6.8); ring sulfoxide 2.7% (0.8-4.9). The erythrocyte and plasma concentrations were significantly correlated. The erythrocyte/plasma concentration ratios, all the erythrocyte concentrations, but none of the plasma concentrations except ring sulfoxide were significantly positively correlated to the dose of thioridazine. The erythrocyte/plasma concentration ratio was not correlated to age. In vitro experiments indicated no clinically relevant erythrocyte-mediated oxidation of thioridazine.

Published
1986
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