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Start Over Descriptor "contact behavior" Journal psychopharmacology
4 results on '"contact behavior"'

1. Modulation of nociception by social factors in rodents: contribution of the opioid system.

Author

D'Amato, Francesca and Pavone, Flaminia

Subjects
*OPIOIDS, *DRUG administration, *NOCICEPTORS, *LABORATORY rodents, *PHYSIOLOGICAL research, *DRUG dosage, *ULTRASONIC imaging
Abstract

Rationale: The opioid system is involved in the regulation of several behavioral and physiological responses, controlling pain, reward, and addictive behaviors. Opioid administration, depending on drugs and doses, usually affects sociability reducing interactions between conspecifics, whereas some affiliative behaviors such as sexual activity, social grooming, and play behavior increase the endogenous opioid activity. Objectives: The possible interaction between endogenous opioids released during socio/sexual behavior and their analgesic effect on pain response is reviewed in the rodent literature. Results: Direct evidence for socially mediated opioid changes resulting in increase in nociceptive threshold derives from studies exploring the effects of defeat experiences, social isolation, maternal, sexual behavior, and social reunion among kin or familiar animals in laboratory rodents. Indirect evidence for endogenous activation of the opioid system, possibly affecting pain sensitivity, derives from studies investigating the relevance of natural social reward using the conditioned place preference protocols or analyzing ultrasonic vocalizations associated to positive affective contexts. Finally, genetic and epigenetic factors that affect the opioid system during development are reported to be involved in modulating the response to social stimuli as well as nociception. Conclusions: All studies highlight the relevance of affiliative contact behavior between conspecifics that is responsible for the activation of the endogenous mu-opioid system, inducing nociceptive threshold increase. [ABSTRACT FROM AUTHOR]

Published
2012
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3. Effects of morphine on different aspects of social play in juvenile rats

Author

Raymond J.M. Niesink, J.M. van Ree, Berry M. Spruijt, and Louk J. M. J. Vanderschuren

Subjects
Male, medicine.medical_specialty, Pharmacology toxicology, Environment, Developmental psychology, Internal medicine, medicine, Animals, Juvenile, Social play, Rats, Wistar, Social isolation, Social Behavior, Pharmacology, Dose-Response Relationship, Drug, Morphine, Contact behavior, Rats, Endocrinology, Social Isolation, Opioid, Exploratory Behavior, Social exploration, medicine.symptom, Psychology, medicine.drug
Abstract

To clarify the influence of opioids on social play, the effects of morphine on playful and non-playful social behavior in juvenile rats was investigated under different conditions. Environmental variables employed were different (dim and intense) levels of illumination during testing, familiarity to the test cage, and different periods of social isolation prior to testing. Under dim light conditions, morphine markedly increased playful social behavior, such as pinning, boxing/wrestling and following/chasing, whereas non-playful social behavior such as social exploration and contact behavior was hardly affected. This effect of morphine was independent of duration of previous isolation and dose-dependent, with a maximal effect at 1.0 mg/kg. The mechanism of this effect is interpreted as an action on the rewarding aspects of play. A dose of 0.1 mg/kg of morphine abolished the initial suppression of play induced by unfamiliarity to the test cage, without influencing total levels of play. This may be an effect of morphine on the integration of sensory stimuli. Under intense light conditions, whereas playful behavior was completely suppressed, morphine itself hardly affected such behavior, but decreased some aspects of non-playful social behavior. These results suggest that in juvenile rats playful and non-playful forms of social behavior are differentially regulated. In addition, opioid systems may be involved at different levels in the regulation of social play.

Published
1995

4. Δ 1-tetrahydrocannabinol but not cannabidiol reduces contact and aggressive behavior of rats tested in dyadic encounters

Author

I. Nir, R.J.M. Niesink, and J.M. van Ree

Subjects
Male, Delta, medicine.medical_specialty, Developmental psychology, Internal medicine, mental disorders, medicine, Social grooming, Animals, Cannabidiol, Humans, Dronabinol, Social isolation, Social Behavior, Tetrahydrocannabinol, Pharmacology, Contact behavior, Cannabinoids, Rats, Inbred Strains, Social relation, Rats, Aggression, Biting, Endocrinology, Social Isolation, medicine.symptom, Psychology, medicine.drug
Abstract

A low and a high dose of delta 1-tetrahydrocannabinol (delta 1-THC) and of cannabidiol (CBD) were IP injected in rats that had been isolated for 7 days. Forty-five minutes after injection, the rats were tested for social interactions with non-isolated, untreated test partners in dyadic encounters under standardized conditions. Different aspects of social behavior were analyzed. The high dose of delta 1-THC (10 mg/kg) prevented nearly all social interactions. The low dose of delta 1-THC (1 mg/kg) exerted selective and specific effects on social interactions. Social contact behavior, including crawl over/mounting, and social grooming, and aggressive behavior, including fighting, kicking, and biting, were markedly decreased, whereas social exploratory behavior (exploration of the partner and anogenital investigation) and the behavioral item, approach/follow, were hardly affected by delta 1-THC treatment. Both doses of CBD (2 and 20 mg/kg) failed to change the various aspects of social interaction. It is postulated that the effects of delta 1-THC on close and intimate contact behavior of rats may contribute to the understanding of marihuana taking in humans.

Published
1984

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