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Your search keyword '"Nichols, William C"' showing total 8 results
Start Over Author "Nichols, William C" Journal pulmonary circulation
8 results on '"Nichols, William C"'

1. RASA3 is a Candidate Gene in Sickle Cell Disease‐Associated Pulmonary Hypertension and Pulmonary Arterial Hypertension

Author

Prohaska, Clare C., primary, Zhang, Xu, additional, Schwantes‐An, Tae‐Hwi L., additional, Stearman, Robert S., additional, Hooker, Stanley, additional, Kittles, Rick A., additional, Aldred, Micheala A., additional, Lutz, Katie A., additional, Pauciulo, Michael W., additional, Nichols, William C., additional, Desai, Ankit A., additional, Gordeuk, Victor R., additional, and Machado, Roberto F., additional

Published
2023
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2. Insulin‐like growth factor binding Protein‐4: A novel indicator of pulmonary arterial hypertension severity and survival

Author

Torres, Guillermo, primary, Yang, Jun, additional, Griffiths, Megan, additional, Brandal, Stephanie, additional, Damico, Rachel, additional, Vaidya, Dhananjay, additional, Simpson, Catherine E., additional, Pauciulo, Michael W., additional, Nichols, William C., additional, Ivy, David D., additional, Austin, Eric D., additional, Hassoun, Paul M., additional, and Everett, Allen D., additional

Published
2023
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3. Low‐affinity insulin‐like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival.

Author

Torres, Guillermo, Lancaster, Andrew C., Yang, Jun, Griffiths, Megan, Brandal, Stephanie, Damico, Rachel, Vaidya, Dhananjay, Simpson, Catherine E., Martin, Lisa J., Pauciulo, Michael W., Nichols, William C., Ivy, David D., Austin, Eric D., Hassoun, Paul M., and Everett, Allen D.

Abstract

Insulin‐like growth factor (IGF) binding proteins (IGFBPs) are a family of growth factor modifiers, some of which are known to be independently associated with pulmonary arterial hypertension (PAH) survival. IGF factor binding protein 7 (IGFBP7) is a unique low‐affinity IGFBP that, independent of IGF, stimulates prostacyclin production. This study proposed to establish associations between IGFBP7 and PAH severity and survival, using enrollment and longitudinal samples. Serum IGFBP7 levels were significantly elevated in patients with PAH compared to controls. After adjusting for age and sex, logarithmic increases in IGFBP7 were associated with a 20 m shorter six‐minute walk distance (6MWD; p < 0.001), a 2−3 mmHg higher mean right atrial pressure (p < 0.001 and 0.02), and a higher likelihood of a greater REVEAL 2.0 risk category placement (p < 0.001). Kaplan−Meier analysis demonstrated significantly decreased survival with IGFBP7 above the median and Cox multivariable analysis adjusted for age and sex, demonstrated higher serum IGFBP7 was an independent predictor of survival. Though the exact mechanism is still unknown, given IGFBP7's role as a prostacyclin stimulant, it has potential use as a therapeutic target for disease modulation. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival

Author

Yang, Jun, primary, Ambade, Anjira S., additional, Nies, Melanie, additional, Griffiths, Megan, additional, Damico, Rachel, additional, Vaidya, Dhananjay, additional, Brandal, Stephanie, additional, Pauciulo, Michael W., additional, Lutz, Katie A., additional, Coleman, Anna W., additional, Nichols, William C., additional, Austin, Eric D., additional, Ivy, Dunbar, additional, Hassoun, Paul M., additional, and Everett, Allen D., additional

Published
2022
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6. United States Pulmonary Hypertension Scientific Registry (USPHSR): rationale, design, and clinical implications

Author

Elliott, C. Gregory, primary, Austin, Eric D., additional, Badesch, David, additional, Badlam, Jessica, additional, Benza, Raymond L., additional, Chung, Wendy K., additional, Farber, Harrison W., additional, Feldkircher, Kathy, additional, Frost, Adaani E., additional, Poms, Abby D., additional, Lutz, Katie A., additional, Pauciulo, Michael W., additional, Yu, Chang, additional, and Nichols, William C., additional

Published
2019
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