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The largest systematic review to date of interactions between PPIs and clopidogrel has found that the combination does not increase mortality in patients at risk of heart attacks and strokes. [...]

Dr Matt Doyle gives a round-up of the latest thinking on another key subject area Gout affects approximately three men in 100 aged >45 - male 3:1 female. Urate crystals [...]

Health Technology Assessment recommends H2 receptor antagonists By Daniel Cressey All patients requiring NSAIDs should be prescribed gastroprotectants to safeguard them from adverse events, an NHS-funded study concludes. The researchers [...]

NSAIDs seem to reduce the risk of Barrett's oesophagus progressing to cancer, a US prospective study reports. Researchers followed up 350 people with Barrett's oesophagus for a median of 65.5 [...]

The safety profile of celecoxib is at least as good as that of paracetamol and conventional NSAIDs, a new large-scale study suggests. The Pfizer-funded meta-analysis of 40,000 patients found celecoxib [...]

Long-term use of NSAIDs significantly reduces the risk of oral cancer in current or former smokers but increases deaths from heart disease, a new study finds. Norwegian researchers compared medication [...]

Q: Many patients are now on both aspirin and warfarin. Another patient on warfarin takes diclofenac intermittently for his gout. Is this safe? A: NSAIDS can interfere with warfarin in [...]

New generations of drugs and poorly recognised research are fuelling fresh debates, writes Dr Andrei Calin Rheumatology is awash with controversies: some are a matter of scientific and academic debate, [...]

Papers reviewed Lancet Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti- inflammatory drugs: a randomised trial Chan FKL et al 2002;359:9-13 [...]