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Background Complete and rapid reversal of the effects of neuromuscular blocker drugs is a primary element of safety in anaesthesia. Neuromuscular conduction that is not completely improved leads to post-operative residual curarisation and the development of complications that are related to respiration. Aim of the Work to compare between the effect of neostigmine and sugammadex on the duration of the recovery from neuromuscular blocking agents and postoperative residual curarization and respiratory complications in the obese patients undergoing laparscopic surgery. Patients and Methods We carried out this randomized clinical study on sixty four patients operated upon at General Surgery Department at Armed Forces Hospitals. Patients and Methods: In this study, 64 patients of either sex with average age ranging from 18-65 years, ASA (I,II), submitted for bariatric gastric sleeve operation were included in this study. Patients were randomly classified into 2 equal groups; Group S (sugammadex, n = 32) and group N (neostigmine, n = 32). Results: no significant differences between both groups regarding age, gender, BMI and ASA. But, we showed statistically a high significant difference between both groups regarding TOF0.9 and significant differences between both groups regarding PACU and operative room time. Conclusion This study verified the efficiency of sugammadex over neostigmine for full and timely reversal of neuromuscular blockade induced by a rocuronium, in morbidly obese patients undergoing laparoscopic bariatric surgery.