1. Leukemia incidence among people exposed to chronic radiation from the contaminated Techa River, 1953–2005
- Author
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Elaine Ron, Dale L. Preston, Faith G. Davis, L. Y. Krestinina, S. B. Epifanova, Evgenia Ostroumova, and Alexander V. Akleyev
- Subjects
Adult ,Male ,Oncology ,medicine.medical_specialty ,Neoplasms, Radiation-Induced ,Time Factors ,Biophysics ,Prevalence ,Risk Assessment ,Article ,Russia ,Cohort Studies ,Young Adult ,Radiation Protection ,Rivers ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Humans ,Leukocyte disorder ,Aged ,General Environmental Science ,Aged, 80 and over ,Leukemia ,Radiation ,business.industry ,Incidence (epidemiology) ,Environmental Exposure ,Middle Aged ,medicine.disease ,Confidence interval ,Relative risk ,Immunology ,Cohort ,Female ,business ,Follow-Up Studies ,Cohort study - Abstract
Beginning in 1950, people living on the banks of the Techa River received chronic low-dose-rate internal and external radiation exposures as a result of releases from the Mayak nuclear weapons plutonium production facility in the Southern Urals region of the Russian Federation. The Techa River cohort includes about 30,000 people who resided in riverside villages sometime between 1950 and 1960. Cumulative red bone marrow doses range up to 2 Gy with a mean of 0.3 Gy and a median of 0.2 Gy. Between 1953 and 2005, 93 first primary cases of leukemia, including 23 cases of chronic lymphatic leukemia (CLL), were ascertained among the cohort members. A significant linear dose-response relationship was seen for leukemias other than CLL (P < 0.001), but not for CLL. The estimated excess relative risk per Gy is 4.9 (95% confidence interval (CI): 1.6; 14.3) for leukemias other than CLL and less than 0 (95% upper bound 1.4) for CLL.
- Published
- 2009
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