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Start Over Author "Darrion L. Mitchell" Journal radiation medicine and protection
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1. The potential role of DEK over-expression in the radiation response of head and neck cancer

Author

Hui Xiao, Bismarck Odei, Steven K. Clinton, and Darrion L. Mitchell

Subjects
HPV, Oropharynx, Radiation, DEK, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Objective: To determine if DEK over-expression is associated with radiation resistance in HPV positive head and neck cancer cells. Methods: Control and DEK over-expressing keratinocytes and an HPV positive head and neck cancer cell line respectively were irradiated with 2–10 ​Gy and the impact on cell survival, γ-H2AX (a marker of DNA damage) and RAD51 (homologous recombination) were analyzed via clonogenic assays, and immunofluorescence measurements respectively. Results: Upon exposure to increasing doses of radiation, DEK over-expression in keratinocytes at 2, 4 (P ​

Published
2021
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