1. Clinical outcomes after sentinel lymph node biopsy in clinically node-negative breast cancer patients
- Author
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Chang Ok Suh, Yong Bae Kim, Hee Ji Han, Ju Ree Kim, Hee Rim Nam, and Ki Chang Keum
- Subjects
Neoplasm recurrence ,medicine.medical_specialty ,medicine.medical_treatment ,Sentinel lymph node ,Clinical Investigations ,Metastasis ,Breast cancer ,Sentinel lymph node biopsy ,Axillary lymph node dissection ,Medicine ,Radiology, Nuclear Medicine and imaging ,Lymph node ,business.industry ,Axillary Lymph Node Dissection ,Sentinel node ,medicine.disease ,Surgery ,Radiation therapy ,medicine.anatomical_structure ,Oncology ,Local ,Resection margin ,Original Article ,Radiology ,Breast neoplasms ,business - Abstract
Purpose To evaluate non-sentinel lymph node (LN) status after sentinel lymph node biopsy (SNB) in patients with breast cancer and to identify the predictive factors for disease failure. Materials and methods From January 2006 to December 2007, axillary lymph node (ALN) dissection after SNB was performed for patients with primary invasive breast cancer who had no clinical evidence of LN metastasis. A total of 320 patients were treated with breast-conserving surgery and radiotherapy. Results The median age of patients was 48 years, and the median follow-up time was 72.8 months. Close resection margin (RM) was observed in 13 patients. The median number of dissected SNB was two, and that of total retrieved ALNs was 11. Sentinel node accuracy was 94.7%, and the overall false negative rate (FNR) was 5.3%. Eleven patients experienced treatment failure. Local recurrence, regional LN recurrence, and distant metastasis were identified in 0.9%, 1.9%, and 2.8% of these patients, respectively. Sentinel LN status were not associated with locoregional recurrence (p > 0.05). Close RM was the only significant factor for disease-free survival (DFS) in univariate and multivariate analysis. The 5-year overall survival, DFS, and locoregional DFS were 100%, 96.8%, and 98.1%, respectively. Conclusion In this study, SNB was performed with high accuracy and low FNR and high locoregional control was achieved.
- Published
- 2014