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Your search keyword '"Kuropteva ZV"' showing total 2 results
Start Over Author "Kuropteva ZV" Journal radiobiologiia
2 results on '"Kuropteva ZV"'

1. [Localization of metronidazole in the organs of tumor-bearing animals using electron paramagnetic resonance].

Author

Zhumabaeva TT and Kuropteva ZV

Subjects
Animals, Electron Spin Resonance Spectroscopy, Mice, Tissue Distribution, Metronidazole metabolism, Radiation-Sensitizing Agents metabolism, Sarcoma 37 metabolism, Sarcoma, Experimental metabolism
Abstract

The low-temperature ESR-spectroscopy was used to study the irradiated organs and blood of tumor-bearing animals before and after the administration of metronidazole. The ESR signals of metronidazole anion-radicals were registered in tissues of the animals injected with metronidazole: the intensity of these signals correspondent with the tissues preparation content.

Published
1986

2. [Effect of metronidazole and local irradiation of the tumor on paramagnetic metal complexes of the liver and tumor tissues].

Author

Zhumabaeva TT, Kudriavtsev ME, Voronina SS, and Kuropteva ZV

Subjects
Animals, Binding Sites drug effects, Binding Sites radiation effects, Electron Spin Resonance Spectroscopy, Kinetics, Liver metabolism, Liver radiation effects, Male, Metalloproteins metabolism, Mice, Mice, Inbred Strains, Sarcoma 37 metabolism, Time Factors, Liver drug effects, Metalloproteins radiation effects, Metronidazole therapeutic use, Sarcoma 37 radiotherapy, Sarcoma, Experimental radiotherapy
Abstract

A study was made of changes in the intensity of the ESR signals in tissues of sarcoma-37 and liver of mice after radiation of the tumor, administration of metronidazole, and after the combined effect of the two factors. The most pronounced changes in the ESR signals were induced by metronidazole. An appreciable increase in the content of nitrosyl complexes in the tumor was noted after the combined effect of metronidazole and radiation which was indicative of the radiation-induced formation of a large number of metronidazole anion-radicals in the tumor.

Published
1987

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