1. Impact of spot positional errors in robustly optimized intensity-modulated proton therapy plan of craniospinal irradiation
- Author
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Manthala Padannayil Noufal, Srinivas Chillukuri, Rajesh Tyagarajan, Suresh Rana, Ganapathy Krishnan, Shamurailatpam Dayananda Sharma, Katikeshwar Patro, Rakesh Jalali, and Manikandan Arjunan
- Subjects
Organs at Risk ,Radiation ,business.industry ,Radiotherapy Planning, Computer-Assisted ,Radiotherapy Dosage ,Physical Therapy, Sports Therapy and Rehabilitation ,General Medicine ,Matlab code ,Craniospinal Irradiation ,030218 nuclear medicine & medical imaging ,Intensity (physics) ,03 medical and health sciences ,Gamma analysis ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Proton Therapy ,Humans ,Radiology, Nuclear Medicine and imaging ,Radiotherapy, Intensity-Modulated ,Nuclear medicine ,business ,Proton therapy ,Mathematics - Abstract
We investigated the influence of random spot positioning errors (SPEs) on dosimetric outcomes of robustly optimized intensity-modulated proton therapy (RB-IMPT) plans in craniospinal irradiation (CSI). Six patients with CSI treated using the RB-IMPT technique were selected. An in-house MATLAB code was used to simulate a random SPE of 1 mm in positive, negative, and both directions for 25%, 50%, and 75% of the total spot positions in the nominal plan. The percentage dose variation (ΔD%) in the six nominal and 54 error-introduced plans was evaluated using standard dose-volume indices, line dose difference, and 3D gamma analysis method. The introduction of a random SPE of 1 mm resulted in a reduction in D99%, D98%, and D95% of both CTVs and PTVs by
- Published
- 2021