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Chromium (III) salicylate and Chromium (III) benzoate complexes were prepared using Chromium trioxide and different molar concentrations of salicylic and benzoic acid. Tertiary amyl alcohol and ethanol are used as a solvent. 1HNMR spectra of solid samples were recorded. 1HNMR spectra of metal complexes suggest that deprotonation of - COOH group took place, and the complex formed was not through the -OH of the acid. It confirms the coordination of the ligand to the metal ion through the carboxylic oxygen atom. [ABSTRACT FROM AUTHOR]

3-hydroxy benzoic acid is an organic chemical which can be obtained naturally as well as synthetically. The literature survey reveals its various biological properties viz. antimicrobial, antialgal, antimutagenic, antiestrogenic, hypoglycemic, anti-inflammatory, anti-platelet aggregating, nematicidal, antiviral, antioxidant etc. It is also reported to be used as a preservative in many drugs, cosmetic products, pharmaceuticals, food and beverages. Some derivatives of 3-hydroxybenzoic acid are found to possess direct action on Hbs molecules, inhibit acetic acidinduced oedema and used in the management of sickle cell disease. It also has wide applications in perfumery industries. In this paper, novel ester / hybrid derivative of 3-Hydroxy benzoic acid was synthesized and tested for its potential antibacterial activity. This combinatorial synthesis of novel 3-Hydroxy benzoic ester/hybrid derivative can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates. [ABSTRACT FROM AUTHOR]

Vanillic acid (4-hydroxy-3-methoxy benzoic acid) is a dihydroxybenzoic acid derivative used as a flavoring agent. It is used in the synthesis of various active pharmaceutical ingredients such as Etamivan, Modecainide, Brovanexine, Vanitiolide, Vanyldisulfamide etc. In this paper, novel ester / hybrid derivatives of vanillic acid were synthesized and tested for potential antibacterial activity. This combinatorial synthesis of novel vanillic ester / hybrid derivatives can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates. [ABSTRACT FROM AUTHOR]