1. Tocilizumab: Increase in alanine aminotransferase level : 3 case reports.
- Subjects
- *
TOCILIZUMAB , *AZITHROMYCIN , *ADULT respiratory distress syndrome , *CYTOKINE release syndrome - Abstract
Tocilizumab: Increase in alanine aminotransferase level: 3 case reports B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event In retrospective cohort study of 9 patients admitted to the University Hospital of Burgos, Spain from 1 April 2020 to 11 May 2020, three men aged 48-67 years were described, who had increase in alanine aminotransferase level following off label treatment with tocilizumab for COVID-19-related acute respiratory distress syndrome [ I not all routes and dosages stated; duration of treatments to reactions onsets not stated i ]. Case 1: A 67-year-old man had increase in alanine aminotransferase level following off label treatment with tocilizumab for COVID-19-related acute respiratory distress syndrome: The ex-smoker man admitted to the hospital due to COVID-19-related acute respiratory distress syndrome and received off label treatment with hydroxychloroquine 400 mg/12 hours on day 1 followed by 200 mg/ 12 hours for 5 days, azithromycin 500 mg/ 24 hours for 7 days and then every 48 hours for 14 days, IV bolus methylprednisolone 250 mg/day for 3 days and 2 doses of IV tocilizumab. [Extracted from the article]
- Published
- 2021
- Full Text
- View/download PDF